Heroic Self-Myth Hypothesis
DOI:
https://doi.org/10.5281/zenodo.17711334Keywords:
Heroic Self-Myth, Smerdyakov, Modernist Hero, Default Mode Network, Moral Disintegration, Epic Self-Deception, Neurophenomenology, Identity PathologyAbstract
This article proposes the "Heroic Self-Myth Hypothesis," a transdisciplinary framework explaining a specific pathology of modern identity construction. Through a detailed analysis of Dostoevsky’s Smerdyakov (The Brothers Karamazov) as a conceptual prototype for Joyce’s characters in Ulysses, the article argues that a pervasive psychological mechanism involves transforming banality into pseudo-heroism to compensate for a profound internal vacuum. The hypothesis posits a sequence of neurocognitive and clinical processes: a dysregulated Default Mode Network fails to generate a coherent self-narrative, creating an existential void. This void is managed through performative substitution, where a hyper-vigilant Salience Network directs attention to external appearances as a substitute for internal substance. This process is catalyzed by developmental traumas, including paternal conflict rooted in envy and a traumatic maternal relationship leading to a fixation on physicality as a threat. The resulting moral disengagement and annihilation of a stable ethical core, often justified by a vulgarized "death of God" liberal philosophy, create a psychic vacuum. This vacuum is subsequently colonized by an "epic self-deception," a grandiose cognitive narrative that reframes a mundane life as a mythic journey. Synthesizing literary analysis, neurobiology, and clinical psychology, the article concludes that Smerdyakov represents not merely a literary character but an archetype of moral disintegration. The modernist hero is thus revealed not as an artistic innovation but as the aesthetic realization of a pre-existing psychological type—the individual who, having lost their moral center, elevates their own insignificance to cosmic significance through a self-authored, illusory heroism.
References
Allison, K. L., & Miller, J. G. (2019). The behavioural system for managing social rank and its relationship to psychopathology. Current Opinion in Psychology, 27, 66–70. https://doi.org/10.1016/j.copsyc.2018.08.001
Aphkhazava, D., Sulashvili, N., & Tkemaladze, J. (2025). Stem Cell Systems and Regeneration. Georgian Scientists, 7(1), 271–319. doi : https://doi.org/10.52340/gs.2025.07.01.26
Aphkhazava, D., Sulashvili, N., Maglakelidze, G., & Tkemaladze, J. (2025). Ageless Creatures: Molecular Insights into Organisms That Defy Aging. Georgian Scientists, 7(3), 346–396. doi : https://doi.org/10.52340/gs.2025.07.03.24
Bandura, A. (2016). Moral disengagement: How people do harm and live with themselves. Worth Publishers.
Chichinadze, K. N., & Tkemaladze, D. V. (2008). Centrosomal hypothesis of cellular aging and differentiation. Advances in Gerontology= Uspekhi Gerontologii, 21(3), 367-371.
Chichinadze, K., Lazarashvili, A., & Tkemaladze, J. (2013). RNA in centrosomes: structure and possible functions. Protoplasma, 250(1), 397-405.
Chichinadze, K., Tkemaladze, D., & Lazarashvili, A. (2012). New class of RNA and centrosomal hypothesis of cell aging. Advances in Gerontology= Uspekhi Gerontologii, 25(1), 23-28.
Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012). A new class of RNAs and the centrosomal hypothesis of cell aging. Advances in Gerontology, 2(4), 287-291.
Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012). Discovery of centrosomal RNA and centrosomal hypothesis of cellular ageing and differentiation. Nucleosides, Nucleotides and Nucleic Acids, 31(3), 172-183.
Denny, B. T., Fan, J., & Ochsner, K. N. (2022). The cognitive neuroscience of emotion regulation: A meta-analysis. Nature Reviews Neuroscience, 23(1), 24-43. https://doi.org/10.1038/s41583-021-00528-7
Elfettahi, A. E., & Tkemaladze, J.(2025). The Neuro-Hepatic-Affective Model (NHAM): A Systems Framework for Liver–Brain Modulation of Emotion in Precision Psychiatry. Preprints. doi : https://doi. org/10.20944/preprints202508, 1312, v1.
Fumagalli, M., & Priori, A. (2021). Functional and clinical neuroanatomy of morality. Brain, 135(4), 1156-1172. https://doi.org/10.1093/brain/awr366
Green, M. F., Horan, W. P., & Lee, J. (2022). Social motivation and its neural correlates in schizophrenia: A review and a roadmap for future research. Schizophrenia Bulletin, 48(5), 1017-1026. https://doi.org/10.1093/schbul/sbac045
Harenski, C. L., & Kiehl, K. A. (2022). The cognitive neuroscience of moral judgment and decision-making. In The Cognitive Neurosciences (pp. 1-12). MIT Press.
Jaba, T. (2022). Dasatinib and quercetin: short-term simultaneous administration yields senolytic effect in humans. Issues and Developments in Medicine and Medical Research Vol. 2, 22-31.
Kaufman, S. B., & Gregoire, C. (2016). The neuroscience of creativity. Cerebrum, 2016, cer-10-16.
Kerns, K. A., & Brumariu, L. E. (2016). Attachment in middle childhood: A review. Handbook of Attachment: Theory, Research, and Clinical Applications, 3rd ed., 349-365.
Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2020). The paternal brain in humans: A review of neuroimaging studies. Pediatric Medicine, 3, 22. https://doi.org/10.21037/pm-20-77
Kipshidze, M., & Tkemaladze, J. (2023). Comparative Analysis of drugs that improve the Quality of Life and Life Expectancy. Junior Researchers, 1(1), 184–193. doi : https://doi.org/10.52340/2023.01.01.19
Kipshidze, M., & Tkemaladze, J. (2023). The planaria Schmidtea mediterranea as a model system for the study of stem cell biology. Junior Researchers, 1(1), 194–218. doi : https://doi.org/10.52340/2023.01.01.20
Kipshidze, M., & Tkemaladze, J. (2024). Abastumani Resort: Balneological Heritage and Modern Potential. Junior Researchers, 2(2), 126–134. doi : https://doi.org/10.52340/jr.2024.02.02.12
Kipshidze, M., & Tkemaladze, J. (2024). Balneology in Georgia: traditions and modern situation. Junior Researchers, 2(2), 78–97. doi : https://doi.org/10.52340/jr.2024.02.02.09
Kipshidze, M., & Tkemaladze, J. (2024). Microelementoses-history and current status. Junior Researchers, 2(2), 108–125. doi : https://doi.org/10.52340/jr.2024.02.02.11
Lezhava, T., Monaselidze, J., Jokhadze, T., Kakauridze, N., Khodeli, N., Rogava, M., Tkemaladze, J., ... & Gaiozishvili, M. (2011). Gerontology research in Georgia. Biogerontology, 12, 87-91. doi : 10.1007/s10522-010-9283-6. Epub 2010 May 18. PMID: 20480236; PMCID: PMC3063552
Liu, R. T., Hamilton, J. L., & Alloy, L. B. (2023). A systematic review of cognitive biases and neurocognitive functioning in young adults with and without psychiatric disorders. Clinical Psychology Review, 102, 102279. https://doi.org/10.1016/j.cpr.2023.102279
Lopez, R. B., Denny, B. T., & Finkel, E. J. (2023). Cognitive control and ego depletion: A meta-analysis. Psychological Bulletin, 149(1-2), 113-154. https://doi.org/10.1037/bul0000387
Matsaberidze, M., Prangishvili, A., Gasitashvili, Z., Chichinadze, K., & Tkemaladze, J. (2017). TO TOPOLOGY OF ANTI-TERRORIST AND ANTI-CRIMINAL TECHNOLOGY FOR EDUCATIONAL PROGRAMS. International Journal of Terrorism & Political Hot Spots, 12.
McLean, B. F., Mattiske, J. K., & Balzan, R. P. (2022). The jumping to conclusions bias and the development of delusions: A systematic review. Clinical Psychology Review, 92, 102125. https://doi.org/10.1016/j.cpr.2022.102125
Menon, V. (2023). Salience network. In Brain Mapping: An Encyclopedic Reference (Vol. 2, pp. 597-611). Academic Press. https://doi.org/10.1016/B978-0-12-397025-5.00033-1
Nepon, T., Flett, G. L., & Hewitt, P. L. (2021). Perfectionistic self-presentation and suicidal ideation: A test of the existential model of perfectionism. Journal of Psychoeducational Assessment, 39(2), 243–258. https://doi.org/10.1177/0734282920977733
Prangishvili, A., Gasitashvili, Z., Matsaberidze, M., Chkhartishvili, L., Chichinadze, K., Tkemaladze, J., ... & Azmaiparashvili, Z. (2019). SYSTEM COMPONENTS OF HEALTH AND INNOVATION FOR THE ORGANIZATION OF NANO-BIOMEDIC ECOSYSTEM TECHNOLOGICAL PLATFORM. Current Politics and Economics of Russia, Eastern and Central Europe, 34(2/3), 299-305.
Riva, P., Williams, K. D., & Gallucci, M. (2022). The neural correlates of social exclusion: A meta-analysis of functional magnetic resonance imaging studies. Social Cognitive and Affective Neuroscience, 17(6), 567-580. https://doi.org/10.1093/scan/nsab139
Röper, M., & van Nieuwenhuizen, H. (2023). Grandiose and vulnerable narcissism: A meta-analysis of their relationship with self-esteem. Personality and Individual Differences, 200, 111897. https://doi.org/10.1016/j.paid.2022.111897
Sass, L. A., & Pienkos, E. (2019). Self-disorder and subjective dimensions of schizophrenia. Current Opinion in Psychiatry, 32(3), 188–196. https://doi.org/10.1097/YCO.0000000000000490
Schalinski, I., Teicher, M. H., Carolus, A. M., & Rockstroh, B. (2019). Early neglect and abuse predict diurnal cortisol patterns in adults: A study of patients with borderline personality disorder and healthy controls. Psychoneuroendocrinology, 100, 50-59. https://doi.org/10.1016/j.psyneuen.2018.09.024
Stowitzki, F., Kollar, B., & Langeloh, M. (2023). Narrative coherence and its relationship to psychological well-being and brain structure. Frontiers in Psychology, 14, 1124581. https://doi.org/10.3389/fpsyg.2023.1124581
Tkemaladze, J. (2025). Bayesian Principles in Ze Systems. Preprints. doi : https://doi.org/10.20944/preprints202510.1287.v1
Tkemaladze, J. (2025). Concept of Death Awareness as an Existential Alarm Clock in the Context of Hypothetical Biological Immortality. Preprints. doi : https://doi.org/10.20944/preprints202510.1067.v1
Tkemaladze, J. (2025). Lakes as Strategic Food Reserves. Preprints. doi : https://doi.org/10.20944/preprints202510.2035.v1
Tkemaladze, J. (2025). Rejuvenation Biotechnology as a Civilizational Safeguard. Preprints. doi : https://doi.org/10.20944/preprints202511.1795.v1
Tkemaladze, J. (2025). The Heroic Self-Myth Hypothesis: A Neuro-Phenomenological Framework for Pathological Self-Narrativization in the Modernist Epoch. Preprints. doi : https://doi.org/10.20944/preprints202511.1774.v1
Tkemaladze, J. (2025). The Tkemaladze Method: Mapping Cell Lineage with Mutant Mitochondrial Transfer. Preprints. doi : https://doi.org/10.20944/preprints202509.2586.v1
Tkemaladze, J. (2025). Uznadze’s Theory of Set: Experimental Diagnostics and Neurocognitive Implications. Preprints. doi : https://doi.org/10.20944/preprints202511.1006.v1
Tkemaladze, J. (2023). Cross-senolytic effects of dasatinib and quercetin in humans. Georgian Scientists, 5(3), 138–152. doi : https://doi.org/10.52340/2023.05.03.15
Tkemaladze, J. (2023). Is the selective accumulation of oldest centrioles in stem cells the main cause of organism ageing?. Georgian Scientists, 5(3), 216–235. doi : https://doi.org/10.52340/2023.05.03.22
Tkemaladze, J. (2023). Long-Term Differences between Regenerations of Head and Tail Fragments in Schmidtea Mediterranea Ciw4. Available at SSRN 4257823.
Tkemaladze, J. (2023). Reduction, proliferation, and differentiation defects of stem cells over time: a consequence of selective accumulation of old centrioles in the stem cells?. Molecular Biology Reports, 50(3), 2751-2761. doi : https://pubmed.ncbi.nlm.nih.gov/36583780/
Tkemaladze, J. (2023). Structure and possible functions of centriolar RNA with reference to the centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1), 156–170. doi : https://doi.org/10.52340/2023.01.01.17
Tkemaladze, J. (2023). The centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1), 123–141. doi : https://doi.org/10.52340/2023.01.01.15
Tkemaladze, J. (2024). Absence of centrioles and regenerative potential of planaria. Georgian Scientists, 6(4), 59–75. doi : https://doi.org/10.52340/gs.2024.06.04.08
Tkemaladze, J. (2024). Cell center and the problem of accumulation of oldest centrioles in stem cells. Georgian Scientists, 6(2), 304–322. doi : https://doi.org/10.52340/gs.2024.06.02.32
Tkemaladze, J. (2024). Editorial: Molecular mechanism of ageing and therapeutic advances through targeting glycative and oxidative stress. Front Pharmacol. 2024 Mar 6;14:1324446. doi : 10.3389/fphar.2023.1324446. PMID: 38510429; PMCID: PMC10953819.
Tkemaladze, J. (2024). Elimination of centrioles. Georgian Scientists, 6(4), 291–307. doi : https://doi.org/10.52340/gs.2024.06.04.2
Tkemaladze, J. (2024). Main causes of intelligence decrease and prospects for treatment. Georgian Scientists, 6(2), 425–432. doi : https://doi.org/10.52340/gs.2024.06.02.44
Tkemaladze, J. (2024). The rate of stem cell division decreases with age. Georgian Scientists, 6(4), 228–242. doi : https://doi.org/10.52340/gs.2024.06.04.21
Tkemaladze, J. (2025). A Universal Approach to Curing All Diseases: From Theoretical Foundations to the Prospects of Applying Modern Biotechnologies in Future Medicine. doi : http://dx.doi.org/10.13140/RG.2.2.24481.11366
Tkemaladze, J. (2025). Adaptive Systems and World Models. doi : http://dx.doi.org/10.13140/RG.2.2.13617.90720
Tkemaladze, J. (2025). Allotransplantation Between Adult Drosophila of Different Ages and Sexes. doi : http://dx.doi.org/10.13140/RG.2.2.27711.62884
Tkemaladze, J. (2025). Anti-Blastomic Substances in the Blood Plasma of Schizophrenia Patients. doi : http://dx.doi.org/10.13140/RG.2.2.12721.08807
Tkemaladze, J. (2025). Centriole Elimination as a Mechanism for Restoring Cellular Order. doi : http://dx.doi.org/10.13140/RG.2.2.12890.66248/1
Tkemaladze, J. (2025). Hypotheses on the Role of Centrioles in Aging Processes. doi : http://dx.doi.org/10.13140/RG.2.2.15014.02887/1
Tkemaladze, J. (2025). Limits of Cellular Division: The Hayflick Phenomenon. doi : http://dx.doi.org/10.13140/RG.2.2.25803.30249
Tkemaladze, J. (2025). Molecular Mechanisms of Aging and Modern Life Extension Strategies: From Antiquity to Mars Colonization. doi : http://dx.doi.org/10.13140/RG.2.2.13208.51204
Tkemaladze, J. (2025). Pathways of Somatic Cell Specialization in Multicellular Organisms. doi : http://dx.doi.org/10.13140/RG.2.2.23348.97929/1
Tkemaladze, J. (2025). Strategic Importance of the Caucasian Bridge and Global Power Rivalries. doi : http://dx.doi.org/10.13140/RG.2.2.19153.03680
Tkemaladze, J. (2025). The Epistemological Reconfiguration and Transubstantial Reinterpretation of Eucharistic Practices Established by the Divine Figure of Jesus Christ in Relation to Theological Paradigms. doi : http://dx.doi.org/10.13140/RG.2.2.28347.73769/1
Tkemaladze, J. (2025). Transforming the psyche with phoneme frequencies "Habere aliam linguam est possidere secundam animam". doi : http://dx.doi.org/10.13140/RG.2.2.16105.61286
Tkemaladze, J. (2025). Uneven Centrosome Inheritance and Its Impact on Cell Fate. doi : http://dx.doi.org/10.13140/RG.2.2.34917.31206
Tkemaladze, J. (2025). Ze World Model with Predicate Actualization and Filtering. doi : http://dx.doi.org/10.13140/RG.2.2.15218.62407
Tkemaladze, J. (2025). Ze метод создания пластичного счетчика хронотропных частот чисел бесконечного потока информации. doi : http://dx.doi.org/10.13140/RG.2.2.29162.43207
Tkemaladze, J. (2025). A Novel Integrated Bioprocessing Strategy for the Manufacturing of Shelf-Stable, Nutritionally Upgraded Activated Wheat: Development of a Comprehensive Protocol, In-Depth Nutritional Characterization, and Evaluation of Biofunctional Properties. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16950787
Tkemaladze, J. (2025). Achieving Perpetual Vitality Through Innovation. doi : http://dx.doi.org/10.13140/RG.2.2.31113.35685
Tkemaladze, J. (2025). Activated Wheat: The Power of Super Grains. Preprints. doi : https://doi.org/10.20944/preprints202508.1724.v1
Tkemaladze, J. (2025). Adaptive Cognitive System Ze. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15309162
Tkemaladze, J. (2025). Aging Model Based on Drosophila melanogaster: Mechanisms and Perspectives. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.14955643
Tkemaladze, J. (2025). Aging Model-Drosophila Melanogaster. doi : http://dx.doi.org/10.13140/RG.2.2.16706.49607
Tkemaladze, J. (2025). An Interdisciplinary Study on the Causes of Antediluvian Longevity, the Postdiluvian Decline in Lifespan, and the Phenomenon of Job’s Life Extension. Preprints. doi : https://doi.org/10.20944/preprints202509.1476.v1
Tkemaladze, J. (2025). Anatomy, Biogenesis, and Role in Cell Biology of Centrioles. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14742232
Tkemaladze, J. (2025). Anti-Blastomic Substances in the Plasma of Schizophrenia Patients: A Dual Role of Complement C4 in Synaptic Pruning and Tumor Suppression. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15042448
Tkemaladze, J. (2025). Asymmetry in the Inheritance of Centrosomes/Centrioles and Its Consequences. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14837352
Tkemaladze, J. (2025). Bayesian Order in Ze. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17359987
Tkemaladze, J. (2025). Centriole Elimination: A Mechanism for Resetting Entropy in the Cell. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14876013
Tkemaladze, J. (2025). Concept of Death Awareness as an Existential Regulator in the Age of Biological Immortality. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17340207
Tkemaladze, J. (2025). Concept to The Alive Language. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14688792
Tkemaladze, J. (2025). Concept to The Caucasian Bridge. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.17643013
Tkemaladze, J. (2025). Concept to The Curing All Diseases. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14676208
Tkemaladze, J. (2025). Concept to The Eternal Youth. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14681902
Tkemaladze, J. (2025). Concept to The Food Security. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14642407
Tkemaladze, J. (2025). Concept to the Living Space. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14635991
Tkemaladze, J. (2025). Concept to The Restoring Dogmas. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14708980
Tkemaladze, J. (2025). Differentiation of Somatic Cells in Multicellular Organisms. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/10.5281/zenodo.14778927
Tkemaladze, J. (2025). Direct Reprogramming of Somatic Cells to Functional Gametes in Planarians via a Novel In Vitro Gametogenesis Protocol. Preprints. doi : https://doi.org/10.20944/preprints202509.1071.v1
Tkemaladze, J. (2025). Induction of germline-like cells (PGCLCs). Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16414775
Tkemaladze, J. (2025). Lake Aquaculture for Catastrophic Food Security. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17454164
Tkemaladze, J. (2025). Long-Lived Non-Renewable Structures in the Human Body. doi : http://dx.doi.org/10.13140/RG.2.2.14826.43206
Tkemaladze, J. (2025). Mechanisms of Learning Through the Actualization of Discrepancies. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15200612
Tkemaladze, J. (2025). Memorizing an Infinite Stream of Information in a Limited Memory Space: The Ze Method of a Plastic Counter of Chronotropic Number Frequencies. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15170931
Tkemaladze, J. (2025). Molecular Insights and Radical Longevity from Ancient Elixirs to Mars Colonies. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14895222
Tkemaladze, J. (2025). Ontogenetic Permanence of Non-Renewable Biomechanical Configurations in Homo Sapiens Anatomy. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15086387
Tkemaladze, J. (2025). Protocol for Transplantation of Healthy Cells Between Adult Drosophila of Different Ages and Sexes. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14889948
Tkemaladze, J. (2025). Replicative Hayflick Limit. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14752664
Tkemaladze, J. (2025). Solutions to the Living Space Problem to Overcome the Fear of Resurrection from the Dead. doi : http://dx.doi.org/10.13140/RG.2.2.34655.57768
Tkemaladze, J. (2025). The Centriolar Theory of Differentiation Explains the Biological Meaning of the Centriolar Theory of Organismal Aging. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.14897688
Tkemaladze, J. (2025). The Centriolar Theory of Differentiation Explains the Biological Meaning of the.
Tkemaladze, J. (2025). The Concept of Data-Driven Automated Governance. Georgian Scientists, 6(4), 399–410. doi : https://doi.org/10.52340/gs.2024.06.04.38
Tkemaladze, J. (2025). The Stage of Differentiation Into Mature Gametes During Gametogenesis in Vitro. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16808827
Tkemaladze, J. (2025). The Tkemaladze Method Maps Cell Lineage with Mutant Mitochondrial Transfer. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17236869
Tkemaladze, J. (2025). The Tkemaladze Method: A Modernized Caucasian Technology for the Production of Shelf-Stable Activated Wheat with Enhanced Nutritional Properties. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16905079
Tkemaladze, J. (2025). Theory of Lifespan Decline. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17142909
Tkemaladze, J. (2025). Through In Vitro Gametogenesis—Young Stem Cells. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15847116
Tkemaladze, J. (2025). Tkemaladze, J. (2025). The Centriole Paradox in Planarian Biology: Why Acentriolar Stem Cells Divide and Centriolar Somatic Cells Do Not. Preprints. doi : https://doi.org/10.20944/preprints202509.0382.v1
Tkemaladze, J. (2025). Unlocking the Voynich Cipher via the New Algorithmic Coding Hypothesis. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17054312
Tkemaladze, J. (2025). Uznadze Set Revisited. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17609772
Tkemaladze, J. (2025). Voynich Manuscript Decryption: A Novel Compression-Based Hypothesis and Computational Framework. Preprints. doi : https://doi.org/10.20944/preprints202509.0403.v1
Tkemaladze, J. (2025). Why do planarian cells without centrioles divide and cells with centrioles do not divide?. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17054142
Tkemaladze, J. (2025). Гаметогенез In Vitro: современное состояние, технологии и перспективы применения. Research Gate. doi : http://dx.doi.org/10.13140/RG.2.2.28647.36000
Tkemaladze, J. Systemic Resilience and Sustainable Nutritional Paradigms in Anthropogenic Ecosystems. doi : http://dx.doi.org/10.13140/RG.2.2.18943.32169/1
Tkemaladze, J. V., & Chichinadze, K. N. (2005). Centriolar mechanisms of differentiation and replicative aging of higher animal cells. Biochemistry (Moscow), 70, 1288-1303.
Tkemaladze, J., & Apkhazava, D. (2019). Dasatinib and quercetin: short-term simultaneous administration improves physical capacity in human. J Biomedical Sci, 8(3), 3.
Tkemaladze, J., & Chichinadze, K. (2005). Potential role of centrioles in determining the morphogenetic status of animal somatic cells. Cell biology international, 29(5), 370-374.
Tkemaladze, J., & Chichinadze, K. (2010). Centriole, differentiation, and senescence. Rejuvenation research, 13(2-3), 339-342.
Tkemaladze, J., & Gakely, G. (2025). A Novel Biotechnological Approach for the Production of Shelf-Stable, Nutritionally Enhanced Activated Wheat: Protocol Development, Nutritional Profiling, and Bioactivity Assessment. doi : https://doi.org/10.20944/preprints202508.1997.v1
Tkemaladze, J., & Gakely, G. (2025). Induction of de novo centriole biogenesis in planarian stem cells. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17283229
Tkemaladze, J., & Samanishvili, T. (2024). Mineral ice cream improves recovery of muscle functions after exercise. Georgian Scientists, 6(2), 36–50. doi : https://doi.org/10.52340/gs.2024.06.02.04
Tkemaladze, J., Gakely, G., Gegelia, L., Papadopulo, I., Taktakidze, A., Metreveli, N., ... & Maglakelidze, U. (2025). Production of Functional Gametes from Somatic Cells of the Planarian Schmidtea Mediterranea Via in Vitro Gametogenesis. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17131291
Tkemaladze, J., Tavartkiladze, A., & Chichinadze, K. (2012). Programming and Implementation of Age-Related Changes. In Senescence. IntechOpen.
Tkemaladze, Jaba and Kipshidze, Mariam, Regeneration Potential of the Schmidtea Mediterranea CIW4 Planarian. Available at SSRN: https://ssrn.com/abstract=4633202 or http://dx.doi.org/10.2139/ssrn.4633202
Tottenham, N. (2020). Early adversity and the neocortical development of the HPA axis. Neuropsychopharmacology, 45(1), 1-14. https://doi.org/10.1038/s41386-019-0444-2
Vogel, D. H. (2022). The neural correlates of the narrative self: A meta-analysis of neuroimaging studies. Social Cognitive and Affective Neuroscience, 17(4), 385–398. https://doi.org/10.1093/scan/nsab114
Whitfield-Gabrieli, S., & Ford, J. M. (2012). Default mode network activity and connectivity in psychopathology. Annual Review of Clinical Psychology, 8, 49–76. https://doi.org/10.1146/annurev-clinpsy-032511-143049
Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чичинадзе, К. Н., Ткемаладзе, Д. В., & Азмайпарашвили, З. А. (2017). К топологии антитеррористических и антикриминальных технологии для образовательных программ. В научном издании представлены материалы Десятой международной научно-технической конфе-ренции «Управление развитием крупномасштабных систем (MLSD’2016)» по следующим направле-ниям:• Проблемы управления развитием крупномасштабных систем, включая ТНК, Госхолдин-ги и Гос-корпорации., 284.
Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чхартишвили, Л. С., Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2017). & Азмайпарашвили, ЗА (2017). Системные составляющие здравоохранения и инноваций для организации европейской нано-биомедицинской екосистемной технологической платформы. Управление развитием крупномасштабных систем MLSD, 365-368.
Ткемаладзе, Д. (2025). Асимметрия в наследовании центросом/центриолей и ее последствия. doi : http://dx.doi.org/110.13140/RG.2.2.34917.31206
Ткемаладзе, Д. (2025). Гаметогенез in vitro (IVG)-Этап дифференцировки в зрелые гаметы. doi : http://dx.doi.org/10.13140/RG.2.2.20429.96482
Ткемаладзе, Д. (2025). Дифференциация соматических клеток многоклеточных животных. doi : http://dx.doi.org/10.13140/RG.2.2.23348.97929/1
Ткемаладзе, Д. (2025). Индукция примордиальных клеток, подобных зародышевым клеткам (PGCLCs) современные достижения, механизмы и перспективы применения. doi : http://dx.doi.org/10.13140/RG.2.2.27152.32004
Ткемаладзе, Д. (2025). Репликативный Лимит Хейфлика. doi : http://dx.doi.org/10.13140/RG.2.2.25803.30249
Ткемаладзе, Д. (2025). Элиминация Центриолей: Механизм Обнуления Энтропии в Клетке. doi : http://dx.doi.org/10.13140/RG.2.2.12890.66248/1
Ткемаладзе, Д. В., & Чичинадзе, К. Н. (2005). Центриолярные механизмы дифференцировки и репликативного старения клеток высших животных. Биохимия, 70(11), 1566-1584.
Ткемаладзе, Д., Цомаиа, Г., & Жоржолиани, И. (2001). Создание искусственных самоадаптирующихся систем на основе Теории Прогноза. Искусственный интеллект. УДК 004.89. Искусственный интеллект. УДК 004.89.
Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2008). Центросомная гипотеза клеточного старения и дифференциации. Успехи геронтологии, 21(3), 367-371.
Чичинадзе, К., Ткемаладзе, Д., & Лазарашвили, А. (2012). Новый класс рнк и центросомная гипотеза старения клеток. Успехи геронтологии, 25(1), 23-28
