Heroic Self-Myth Hypothesis

Article Sidebar

PDF
Published: 2025-11-25
DOI: https://doi.org/10.5281/zenodo.17711334
Keywords:
Heroic Self-Myth, Smerdyakov, Modernist Hero, Default Mode Network, Moral Disintegration, Epic Self-Deception, Neurophenomenology, Identity Pathology

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

This article proposes the "Heroic Self-Myth Hypothesis," a transdisciplinary framework explaining a specific pathology of modern identity construction. Through a detailed analysis of Dostoevsky’s Smerdyakov (The Brothers Karamazov) as a conceptual prototype for Joyce’s characters in Ulysses, the article argues that a pervasive psychological mechanism involves transforming banality into pseudo-heroism to compensate for a profound internal vacuum. The hypothesis posits a sequence of neurocognitive and clinical processes: a dysregulated Default Mode Network fails to generate a coherent self-narrative, creating an existential void. This void is managed through performative substitution, where a hyper-vigilant Salience Network directs attention to external appearances as a substitute for internal substance. This process is catalyzed by developmental traumas, including paternal conflict rooted in envy and a traumatic maternal relationship leading to a fixation on physicality as a threat. The resulting moral disengagement and annihilation of a stable ethical core, often justified by a vulgarized "death of God" liberal philosophy, create a psychic vacuum. This vacuum is subsequently colonized by an "epic self-deception," a grandiose cognitive narrative that reframes a mundane life as a mythic journey. Synthesizing literary analysis, neurobiology, and clinical psychology, the article concludes that Smerdyakov represents not merely a literary character but an archetype of moral disintegration. The modernist hero is thus revealed not as an artistic innovation but as the aesthetic realization of a pre-existing psychological type—the individual who, having lost their moral center, elevates their own insignificance to cosmic significance through a self-authored, illusory heroism.

Article Details

Issue

Vol. 1 No. 4 (2025)

Section

Opinion and Commentary
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

The Goal of Dr. Jaba Tkemaladze - Systemic Rejuvenation Through in Vitro–Derived Safe Adult Stem Cells and Their Transplantation. His theoretical works include the development of the Centriolar Theory of Differentiation and the Centriolar Theory of Organismal Aging, which suggest the role of centrioles in the aging and development of cells and tissues. President, Longevity Alliance Georgia. Head of Department, Longevity Clinic, Inc., Georgia.

 

A physician-scientist specializing in the biology of ageing and longevity. His research focuses on the potential of stem cell therapies for age-related diseases and healthspan extension.

Current Roles:

  • President, Longevity Alliance Georgia.
  • Head of Department, Longevity Clinic, Inc., Georgia.

Research Focus:
His main research is related to the study of methodologies for returning the regeneration rate to the indicators of 12-24 years, in particular with the potential application of the technology of producing young safe stem cells from one's own somatic cells. His theoretical works include the development of the Centriolar Theory of Differentiation and the Centriolar Theory of Organismal Aging, which suggest the role of centrioles in the aging and development of cells and tissues.

Background:
Dr. Tkemaladze received his medical education at the Tbilisi State Medical University and continued his research in the laboratories of the Institute of Morphology and the Research Institute of Psychiatry. In his work, he uses a combined approach, combining experimental and computational methods, to study the aging process and develop treatments for age-related diseases.

Service and Recognition:
He has served on scientific advisory boards, including for the Georgian Ministry of Defense and the Longevity Alliance. He is the author of over 100 scientific publications and has been an invited speaker at numerous national and international conferences.

How to Cite

Tkemaladze, J. (2025). Heroic Self-Myth Hypothesis. Longevity Horizon, 1(4). DOI:https://doi.org/10.5281/zenodo.17711334
Crossref
Scopus
Google Scholar
Europe PMC

References

Allison, K. L., & Miller, J. G. (2019). The behavioural system for managing social rank and its relationship to psychopathology. Current Opinion in Psychology, 27, 66–70. https://doi.org/10.1016/j.copsyc.2018.08.001

Aphkhazava, D., Sulashvili, N., & Tkemaladze, J. (2025). Stem Cell Systems and Regeneration. Georgian Scientists, 7(1), 271–319. doi : https://doi.org/10.52340/gs.2025.07.01.26

Aphkhazava, D., Sulashvili, N., Maglakelidze, G., & Tkemaladze, J. (2025). Ageless Creatures: Molecular Insights into Organisms That Defy Aging. Georgian Scientists, 7(3), 346–396. doi : https://doi.org/10.52340/gs.2025.07.03.24

Bandura, A. (2016). Moral disengagement: How people do harm and live with themselves. Worth Publishers.

Chichinadze, K. N., & Tkemaladze, D. V. (2008). Centrosomal hypothesis of cellular aging and differentiation. Advances in Gerontology= Uspekhi Gerontologii, 21(3), 367-371.

Chichinadze, K., Lazarashvili, A., & Tkemaladze, J. (2013). RNA in centrosomes: structure and possible functions. Protoplasma, 250(1), 397-405.

Chichinadze, K., Tkemaladze, D., & Lazarashvili, A. (2012). New class of RNA and centrosomal hypothesis of cell aging. Advances in Gerontology= Uspekhi Gerontologii, 25(1), 23-28.

Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012). A new class of RNAs and the centrosomal hypothesis of cell aging. Advances in Gerontology, 2(4), 287-291.

Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012). Discovery of centrosomal RNA and centrosomal hypothesis of cellular ageing and differentiation. Nucleosides, Nucleotides and Nucleic Acids, 31(3), 172-183.

Denny, B. T., Fan, J., & Ochsner, K. N. (2022). The cognitive neuroscience of emotion regulation: A meta-analysis. Nature Reviews Neuroscience, 23(1), 24-43. https://doi.org/10.1038/s41583-021-00528-7

Elfettahi, A. E., & Tkemaladze, J.(2025). The Neuro-Hepatic-Affective Model (NHAM): A Systems Framework for Liver–Brain Modulation of Emotion in Precision Psychiatry. Preprints. doi : https://doi. org/10.20944/preprints202508, 1312, v1.

Fumagalli, M., & Priori, A. (2021). Functional and clinical neuroanatomy of morality. Brain, 135(4), 1156-1172. https://doi.org/10.1093/brain/awr366

Green, M. F., Horan, W. P., & Lee, J. (2022). Social motivation and its neural correlates in schizophrenia: A review and a roadmap for future research. Schizophrenia Bulletin, 48(5), 1017-1026. https://doi.org/10.1093/schbul/sbac045

Harenski, C. L., & Kiehl, K. A. (2022). The cognitive neuroscience of moral judgment and decision-making. In The Cognitive Neurosciences (pp. 1-12). MIT Press.

Jaba, T. (2022). Dasatinib and quercetin: short-term simultaneous administration yields senolytic effect in humans. Issues and Developments in Medicine and Medical Research Vol. 2, 22-31.

Kaufman, S. B., & Gregoire, C. (2016). The neuroscience of creativity. Cerebrum, 2016, cer-10-16.

Kerns, K. A., & Brumariu, L. E. (2016). Attachment in middle childhood: A review. Handbook of Attachment: Theory, Research, and Clinical Applications, 3rd ed., 349-365.

Kim, S., Kwok, S., Mayes, L. C., Potenza, M. N., Rutherford, H. J. V., & Strathearn, L. (2020). The paternal brain in humans: A review of neuroimaging studies. Pediatric Medicine, 3, 22. https://doi.org/10.21037/pm-20-77

Kipshidze, M., & Tkemaladze, J. (2023). Comparative Analysis of drugs that improve the Quality of Life and Life Expectancy. Junior Researchers, 1(1), 184–193. doi : https://doi.org/10.52340/2023.01.01.19

Kipshidze, M., & Tkemaladze, J. (2023). The planaria Schmidtea mediterranea as a model system for the study of stem cell biology. Junior Researchers, 1(1), 194–218. doi : https://doi.org/10.52340/2023.01.01.20

Kipshidze, M., & Tkemaladze, J. (2024). Abastumani Resort: Balneological Heritage and Modern Potential. Junior Researchers, 2(2), 126–134. doi : https://doi.org/10.52340/jr.2024.02.02.12

Kipshidze, M., & Tkemaladze, J. (2024). Balneology in Georgia: traditions and modern situation. Junior Researchers, 2(2), 78–97. doi : https://doi.org/10.52340/jr.2024.02.02.09

Kipshidze, M., & Tkemaladze, J. (2024). Microelementoses-history and current status. Junior Researchers, 2(2), 108–125. doi : https://doi.org/10.52340/jr.2024.02.02.11

Lezhava, T., Monaselidze, J., Jokhadze, T., Kakauridze, N., Khodeli, N., Rogava, M., Tkemaladze, J., ... & Gaiozishvili, M. (2011). Gerontology research in Georgia. Biogerontology, 12, 87-91. doi : 10.1007/s10522-010-9283-6. Epub 2010 May 18. PMID: 20480236; PMCID: PMC3063552

Liu, R. T., Hamilton, J. L., & Alloy, L. B. (2023). A systematic review of cognitive biases and neurocognitive functioning in young adults with and without psychiatric disorders. Clinical Psychology Review, 102, 102279. https://doi.org/10.1016/j.cpr.2023.102279

Lopez, R. B., Denny, B. T., & Finkel, E. J. (2023). Cognitive control and ego depletion: A meta-analysis. Psychological Bulletin, 149(1-2), 113-154. https://doi.org/10.1037/bul0000387

Matsaberidze, M., Prangishvili, A., Gasitashvili, Z., Chichinadze, K., & Tkemaladze, J. (2017). TO TOPOLOGY OF ANTI-TERRORIST AND ANTI-CRIMINAL TECHNOLOGY FOR EDUCATIONAL PROGRAMS. International Journal of Terrorism & Political Hot Spots, 12.

McLean, B. F., Mattiske, J. K., & Balzan, R. P. (2022). The jumping to conclusions bias and the development of delusions: A systematic review. Clinical Psychology Review, 92, 102125. https://doi.org/10.1016/j.cpr.2022.102125

Menon, V. (2023). Salience network. In Brain Mapping: An Encyclopedic Reference (Vol. 2, pp. 597-611). Academic Press. https://doi.org/10.1016/B978-0-12-397025-5.00033-1

Nepon, T., Flett, G. L., & Hewitt, P. L. (2021). Perfectionistic self-presentation and suicidal ideation: A test of the existential model of perfectionism. Journal of Psychoeducational Assessment, 39(2), 243–258. https://doi.org/10.1177/0734282920977733

Prangishvili, A., Gasitashvili, Z., Matsaberidze, M., Chkhartishvili, L., Chichinadze, K., Tkemaladze, J., ... & Azmaiparashvili, Z. (2019). SYSTEM COMPONENTS OF HEALTH AND INNOVATION FOR THE ORGANIZATION OF NANO-BIOMEDIC ECOSYSTEM TECHNOLOGICAL PLATFORM. Current Politics and Economics of Russia, Eastern and Central Europe, 34(2/3), 299-305.

Riva, P., Williams, K. D., & Gallucci, M. (2022). The neural correlates of social exclusion: A meta-analysis of functional magnetic resonance imaging studies. Social Cognitive and Affective Neuroscience, 17(6), 567-580. https://doi.org/10.1093/scan/nsab139

Röper, M., & van Nieuwenhuizen, H. (2023). Grandiose and vulnerable narcissism: A meta-analysis of their relationship with self-esteem. Personality and Individual Differences, 200, 111897. https://doi.org/10.1016/j.paid.2022.111897

Sass, L. A., & Pienkos, E. (2019). Self-disorder and subjective dimensions of schizophrenia. Current Opinion in Psychiatry, 32(3), 188–196. https://doi.org/10.1097/YCO.0000000000000490

Schalinski, I., Teicher, M. H., Carolus, A. M., & Rockstroh, B. (2019). Early neglect and abuse predict diurnal cortisol patterns in adults: A study of patients with borderline personality disorder and healthy controls. Psychoneuroendocrinology, 100, 50-59. https://doi.org/10.1016/j.psyneuen.2018.09.024

Stowitzki, F., Kollar, B., & Langeloh, M. (2023). Narrative coherence and its relationship to psychological well-being and brain structure. Frontiers in Psychology, 14, 1124581. https://doi.org/10.3389/fpsyg.2023.1124581

Tkemaladze, J. (2025). Bayesian Principles in Ze Systems. Preprints. doi : https://doi.org/10.20944/preprints202510.1287.v1

Tkemaladze, J. (2025). Concept of Death Awareness as an Existential Alarm Clock in the Context of Hypothetical Biological Immortality. Preprints. doi : https://doi.org/10.20944/preprints202510.1067.v1

Tkemaladze, J. (2025). Lakes as Strategic Food Reserves. Preprints. doi : https://doi.org/10.20944/preprints202510.2035.v1

Tkemaladze, J. (2025). Rejuvenation Biotechnology as a Civilizational Safeguard. Preprints. doi : https://doi.org/10.20944/preprints202511.1795.v1

Tkemaladze, J. (2025). The Heroic Self-Myth Hypothesis: A Neuro-Phenomenological Framework for Pathological Self-Narrativization in the Modernist Epoch. Preprints. doi : https://doi.org/10.20944/preprints202511.1774.v1

Tkemaladze, J. (2025). The Tkemaladze Method: Mapping Cell Lineage with Mutant Mitochondrial Transfer. Preprints. doi : https://doi.org/10.20944/preprints202509.2586.v1

Tkemaladze, J. (2025). Uznadze’s Theory of Set: Experimental Diagnostics and Neurocognitive Implications. Preprints. doi : https://doi.org/10.20944/preprints202511.1006.v1

Tkemaladze, J. (2023). Cross-senolytic effects of dasatinib and quercetin in humans. Georgian Scientists, 5(3), 138–152. doi : https://doi.org/10.52340/2023.05.03.15

Tkemaladze, J. (2023). Is the selective accumulation of oldest centrioles in stem cells the main cause of organism ageing?. Georgian Scientists, 5(3), 216–235. doi : https://doi.org/10.52340/2023.05.03.22

Tkemaladze, J. (2023). Long-Term Differences between Regenerations of Head and Tail Fragments in Schmidtea Mediterranea Ciw4. Available at SSRN 4257823.

Tkemaladze, J. (2023). Reduction, proliferation, and differentiation defects of stem cells over time: a consequence of selective accumulation of old centrioles in the stem cells?. Molecular Biology Reports, 50(3), 2751-2761. doi : https://pubmed.ncbi.nlm.nih.gov/36583780/

Tkemaladze, J. (2023). Structure and possible functions of centriolar RNA with reference to the centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1), 156–170. doi : https://doi.org/10.52340/2023.01.01.17

Tkemaladze, J. (2023). The centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1), 123–141. doi : https://doi.org/10.52340/2023.01.01.15

Tkemaladze, J. (2024). Absence of centrioles and regenerative potential of planaria. Georgian Scientists, 6(4), 59–75. doi : https://doi.org/10.52340/gs.2024.06.04.08

Tkemaladze, J. (2024). Cell center and the problem of accumulation of oldest centrioles in stem cells. Georgian Scientists, 6(2), 304–322. doi : https://doi.org/10.52340/gs.2024.06.02.32

Tkemaladze, J. (2024). Editorial: Molecular mechanism of ageing and therapeutic advances through targeting glycative and oxidative stress. Front Pharmacol. 2024 Mar 6;14:1324446. doi : 10.3389/fphar.2023.1324446. PMID: 38510429; PMCID: PMC10953819.

Tkemaladze, J. (2024). Elimination of centrioles. Georgian Scientists, 6(4), 291–307. doi : https://doi.org/10.52340/gs.2024.06.04.2

Tkemaladze, J. (2024). Main causes of intelligence decrease and prospects for treatment. Georgian Scientists, 6(2), 425–432. doi : https://doi.org/10.52340/gs.2024.06.02.44

Tkemaladze, J. (2024). The rate of stem cell division decreases with age. Georgian Scientists, 6(4), 228–242. doi : https://doi.org/10.52340/gs.2024.06.04.21

Tkemaladze, J. (2025). A Universal Approach to Curing All Diseases: From Theoretical Foundations to the Prospects of Applying Modern Biotechnologies in Future Medicine. doi : http://dx.doi.org/10.13140/RG.2.2.24481.11366

Tkemaladze, J. (2025). Adaptive Systems and World Models. doi : http://dx.doi.org/10.13140/RG.2.2.13617.90720

Tkemaladze, J. (2025). Allotransplantation Between Adult Drosophila of Different Ages and Sexes. doi : http://dx.doi.org/10.13140/RG.2.2.27711.62884

Tkemaladze, J. (2025). Anti-Blastomic Substances in the Blood Plasma of Schizophrenia Patients. doi : http://dx.doi.org/10.13140/RG.2.2.12721.08807

Tkemaladze, J. (2025). Centriole Elimination as a Mechanism for Restoring Cellular Order. doi : http://dx.doi.org/10.13140/RG.2.2.12890.66248/1

Tkemaladze, J. (2025). Hypotheses on the Role of Centrioles in Aging Processes. doi : http://dx.doi.org/10.13140/RG.2.2.15014.02887/1

Tkemaladze, J. (2025). Limits of Cellular Division: The Hayflick Phenomenon. doi : http://dx.doi.org/10.13140/RG.2.2.25803.30249

Tkemaladze, J. (2025). Molecular Mechanisms of Aging and Modern Life Extension Strategies: From Antiquity to Mars Colonization. doi : http://dx.doi.org/10.13140/RG.2.2.13208.51204

Tkemaladze, J. (2025). Pathways of Somatic Cell Specialization in Multicellular Organisms. doi : http://dx.doi.org/10.13140/RG.2.2.23348.97929/1

Tkemaladze, J. (2025). Strategic Importance of the Caucasian Bridge and Global Power Rivalries. doi : http://dx.doi.org/10.13140/RG.2.2.19153.03680

Tkemaladze, J. (2025). The Epistemological Reconfiguration and Transubstantial Reinterpretation of Eucharistic Practices Established by the Divine Figure of Jesus Christ in Relation to Theological Paradigms. doi : http://dx.doi.org/10.13140/RG.2.2.28347.73769/1

Tkemaladze, J. (2025). Transforming the psyche with phoneme frequencies "Habere aliam linguam est possidere secundam animam". doi : http://dx.doi.org/10.13140/RG.2.2.16105.61286

Tkemaladze, J. (2025). Uneven Centrosome Inheritance and Its Impact on Cell Fate. doi : http://dx.doi.org/10.13140/RG.2.2.34917.31206

Tkemaladze, J. (2025). Ze World Model with Predicate Actualization and Filtering. doi : http://dx.doi.org/10.13140/RG.2.2.15218.62407

Tkemaladze, J. (2025). Ze метод создания пластичного счетчика хронотропных частот чисел бесконечного потока информации. doi : http://dx.doi.org/10.13140/RG.2.2.29162.43207

Tkemaladze, J. (2025). A Novel Integrated Bioprocessing Strategy for the Manufacturing of Shelf-Stable, Nutritionally Upgraded Activated Wheat: Development of a Comprehensive Protocol, In-Depth Nutritional Characterization, and Evaluation of Biofunctional Properties. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16950787

Tkemaladze, J. (2025). Achieving Perpetual Vitality Through Innovation. doi : http://dx.doi.org/10.13140/RG.2.2.31113.35685

Tkemaladze, J. (2025). Activated Wheat: The Power of Super Grains. Preprints. doi : https://doi.org/10.20944/preprints202508.1724.v1

Tkemaladze, J. (2025). Adaptive Cognitive System Ze. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15309162

Tkemaladze, J. (2025). Aging Model Based on Drosophila melanogaster: Mechanisms and Perspectives. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.14955643

Tkemaladze, J. (2025). Aging Model-Drosophila Melanogaster. doi : http://dx.doi.org/10.13140/RG.2.2.16706.49607

Tkemaladze, J. (2025). An Interdisciplinary Study on the Causes of Antediluvian Longevity, the Postdiluvian Decline in Lifespan, and the Phenomenon of Job’s Life Extension. Preprints. doi : https://doi.org/10.20944/preprints202509.1476.v1

Tkemaladze, J. (2025). Anatomy, Biogenesis, and Role in Cell Biology of Centrioles. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14742232

Tkemaladze, J. (2025). Anti-Blastomic Substances in the Plasma of Schizophrenia Patients: A Dual Role of Complement C4 in Synaptic Pruning and Tumor Suppression. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15042448

Tkemaladze, J. (2025). Asymmetry in the Inheritance of Centrosomes/Centrioles and Its Consequences. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14837352

Tkemaladze, J. (2025). Bayesian Order in Ze. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17359987

Tkemaladze, J. (2025). Centriole Elimination: A Mechanism for Resetting Entropy in the Cell. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14876013

Tkemaladze, J. (2025). Concept of Death Awareness as an Existential Regulator in the Age of Biological Immortality. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17340207

Tkemaladze, J. (2025). Concept to The Alive Language. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14688792

Tkemaladze, J. (2025). Concept to The Caucasian Bridge. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.17643013

Tkemaladze, J. (2025). Concept to The Curing All Diseases. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14676208

Tkemaladze, J. (2025). Concept to The Eternal Youth. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14681902

Tkemaladze, J. (2025). Concept to The Food Security. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14642407

Tkemaladze, J. (2025). Concept to the Living Space. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14635991

Tkemaladze, J. (2025). Concept to The Restoring Dogmas. Longevity Horizon, 1(1). doi : https://doi.org/10.5281/zenodo.14708980

Tkemaladze, J. (2025). Differentiation of Somatic Cells in Multicellular Organisms. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/10.5281/zenodo.14778927

Tkemaladze, J. (2025). Direct Reprogramming of Somatic Cells to Functional Gametes in Planarians via a Novel In Vitro Gametogenesis Protocol. Preprints. doi : https://doi.org/10.20944/preprints202509.1071.v1

Tkemaladze, J. (2025). Induction of germline-like cells (PGCLCs). Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16414775

Tkemaladze, J. (2025). Lake Aquaculture for Catastrophic Food Security. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17454164

Tkemaladze, J. (2025). Long-Lived Non-Renewable Structures in the Human Body. doi : http://dx.doi.org/10.13140/RG.2.2.14826.43206

Tkemaladze, J. (2025). Mechanisms of Learning Through the Actualization of Discrepancies. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15200612

Tkemaladze, J. (2025). Memorizing an Infinite Stream of Information in a Limited Memory Space: The Ze Method of a Plastic Counter of Chronotropic Number Frequencies. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15170931

Tkemaladze, J. (2025). Molecular Insights and Radical Longevity from Ancient Elixirs to Mars Colonies. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14895222

Tkemaladze, J. (2025). Ontogenetic Permanence of Non-Renewable Biomechanical Configurations in Homo Sapiens Anatomy. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15086387

Tkemaladze, J. (2025). Protocol for Transplantation of Healthy Cells Between Adult Drosophila of Different Ages and Sexes. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14889948

Tkemaladze, J. (2025). Replicative Hayflick Limit. Longevity Horizon, 1(2). doi : https://doi.org/10.5281/zenodo.14752664

Tkemaladze, J. (2025). Solutions to the Living Space Problem to Overcome the Fear of Resurrection from the Dead. doi : http://dx.doi.org/10.13140/RG.2.2.34655.57768

Tkemaladze, J. (2025). The Centriolar Theory of Differentiation Explains the Biological Meaning of the Centriolar Theory of Organismal Aging. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.14897688

Tkemaladze, J. (2025). The Centriolar Theory of Differentiation Explains the Biological Meaning of the.

Tkemaladze, J. (2025). The Concept of Data-Driven Automated Governance. Georgian Scientists, 6(4), 399–410. doi : https://doi.org/10.52340/gs.2024.06.04.38

Tkemaladze, J. (2025). The Stage of Differentiation Into Mature Gametes During Gametogenesis in Vitro. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16808827

Tkemaladze, J. (2025). The Tkemaladze Method Maps Cell Lineage with Mutant Mitochondrial Transfer. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17236869

Tkemaladze, J. (2025). The Tkemaladze Method: A Modernized Caucasian Technology for the Production of Shelf-Stable Activated Wheat with Enhanced Nutritional Properties. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.16905079

Tkemaladze, J. (2025). Theory of Lifespan Decline. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17142909

Tkemaladze, J. (2025). Through In Vitro Gametogenesis—Young Stem Cells. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15847116

Tkemaladze, J. (2025). Tkemaladze, J. (2025). The Centriole Paradox in Planarian Biology: Why Acentriolar Stem Cells Divide and Centriolar Somatic Cells Do Not. Preprints. doi : https://doi.org/10.20944/preprints202509.0382.v1

Tkemaladze, J. (2025). Unlocking the Voynich Cipher via the New Algorithmic Coding Hypothesis. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17054312

Tkemaladze, J. (2025). Uznadze Set Revisited. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17609772

Tkemaladze, J. (2025). Voynich Manuscript Decryption: A Novel Compression-Based Hypothesis and Computational Framework. Preprints. doi : https://doi.org/10.20944/preprints202509.0403.v1

Tkemaladze, J. (2025). Why do planarian cells without centrioles divide and cells with centrioles do not divide?. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17054142

Tkemaladze, J. (2025). Гаметогенез In Vitro: современное состояние, технологии и перспективы применения. Research Gate. doi : http://dx.doi.org/10.13140/RG.2.2.28647.36000

Tkemaladze, J. Systemic Resilience and Sustainable Nutritional Paradigms in Anthropogenic Ecosystems. doi : http://dx.doi.org/10.13140/RG.2.2.18943.32169/1

Tkemaladze, J. V., & Chichinadze, K. N. (2005). Centriolar mechanisms of differentiation and replicative aging of higher animal cells. Biochemistry (Moscow), 70, 1288-1303.

Tkemaladze, J., & Apkhazava, D. (2019). Dasatinib and quercetin: short-term simultaneous administration improves physical capacity in human. J Biomedical Sci, 8(3), 3.

Tkemaladze, J., & Chichinadze, K. (2005). Potential role of centrioles in determining the morphogenetic status of animal somatic cells. Cell biology international, 29(5), 370-374.

Tkemaladze, J., & Chichinadze, K. (2010). Centriole, differentiation, and senescence. Rejuvenation research, 13(2-3), 339-342.

Tkemaladze, J., & Gakely, G. (2025). A Novel Biotechnological Approach for the Production of Shelf-Stable, Nutritionally Enhanced Activated Wheat: Protocol Development, Nutritional Profiling, and Bioactivity Assessment. doi : https://doi.org/10.20944/preprints202508.1997.v1

Tkemaladze, J., & Gakely, G. (2025). Induction of de novo centriole biogenesis in planarian stem cells. Longevity Horizon, 1(4). doi : https://doi.org/10.5281/zenodo.17283229

Tkemaladze, J., & Samanishvili, T. (2024). Mineral ice cream improves recovery of muscle functions after exercise. Georgian Scientists, 6(2), 36–50. doi : https://doi.org/10.52340/gs.2024.06.02.04

Tkemaladze, J., Gakely, G., Gegelia, L., Papadopulo, I., Taktakidze, A., Metreveli, N., ... & Maglakelidze, U. (2025). Production of Functional Gametes from Somatic Cells of the Planarian Schmidtea Mediterranea Via in Vitro Gametogenesis. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.17131291

Tkemaladze, J., Tavartkiladze, A., & Chichinadze, K. (2012). Programming and Implementation of Age-Related Changes. In Senescence. IntechOpen.

Tkemaladze, Jaba and Kipshidze, Mariam, Regeneration Potential of the Schmidtea Mediterranea CIW4 Planarian. Available at SSRN: https://ssrn.com/abstract=4633202 or http://dx.doi.org/10.2139/ssrn.4633202

Tottenham, N. (2020). Early adversity and the neocortical development of the HPA axis. Neuropsychopharmacology, 45(1), 1-14. https://doi.org/10.1038/s41386-019-0444-2

Vogel, D. H. (2022). The neural correlates of the narrative self: A meta-analysis of neuroimaging studies. Social Cognitive and Affective Neuroscience, 17(4), 385–398. https://doi.org/10.1093/scan/nsab114

Whitfield-Gabrieli, S., & Ford, J. M. (2012). Default mode network activity and connectivity in psychopathology. Annual Review of Clinical Psychology, 8, 49–76. https://doi.org/10.1146/annurev-clinpsy-032511-143049

Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чичинадзе, К. Н., Ткемаладзе, Д. В., & Азмайпарашвили, З. А. (2017). К топологии антитеррористических и антикриминальных технологии для образовательных программ. В научном издании представлены материалы Десятой международной научно-технической конфе-ренции «Управление развитием крупномасштабных систем (MLSD’2016)» по следующим направле-ниям:• Проблемы управления развитием крупномасштабных систем, включая ТНК, Госхолдин-ги и Гос-корпорации., 284.

Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чхартишвили, Л. С., Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2017). & Азмайпарашвили, ЗА (2017). Системные составляющие здравоохранения и инноваций для организации европейской нано-биомедицинской екосистемной технологической платформы. Управление развитием крупномасштабных систем MLSD, 365-368.

Ткемаладзе, Д. (2025). Асимметрия в наследовании центросом/центриолей и ее последствия. doi : http://dx.doi.org/110.13140/RG.2.2.34917.31206

Ткемаладзе, Д. (2025). Гаметогенез in vitro (IVG)-Этап дифференцировки в зрелые гаметы. doi : http://dx.doi.org/10.13140/RG.2.2.20429.96482

Ткемаладзе, Д. (2025). Дифференциация соматических клеток многоклеточных животных. doi : http://dx.doi.org/10.13140/RG.2.2.23348.97929/1

Ткемаладзе, Д. (2025). Индукция примордиальных клеток, подобных зародышевым клеткам (PGCLCs) современные достижения, механизмы и перспективы применения. doi : http://dx.doi.org/10.13140/RG.2.2.27152.32004

Ткемаладзе, Д. (2025). Репликативный Лимит Хейфлика. doi : http://dx.doi.org/10.13140/RG.2.2.25803.30249

Ткемаладзе, Д. (2025). Элиминация Центриолей: Механизм Обнуления Энтропии в Клетке. doi : http://dx.doi.org/10.13140/RG.2.2.12890.66248/1

Ткемаладзе, Д. В., & Чичинадзе, К. Н. (2005). Центриолярные механизмы дифференцировки и репликативного старения клеток высших животных. Биохимия, 70(11), 1566-1584.

Ткемаладзе, Д., Цомаиа, Г., & Жоржолиани, И. (2001). Создание искусственных самоадаптирующихся систем на основе Теории Прогноза. Искусственный интеллект. УДК 004.89. Искусственный интеллект. УДК 004.89.

Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2008). Центросомная гипотеза клеточного старения и дифференциации. Успехи геронтологии, 21(3), 367-371.

Чичинадзе, К., Ткемаладзе, Д., & Лазарашвили, А. (2012). Новый класс рнк и центросомная гипотеза старения клеток. Успехи геронтологии, 25(1), 23-28