Anatomy, Biogenesis, and Role in Cell Biology of Centrioles

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Published: 2025-01-27
DOI: https://doi.org/10.5281/zenodo.14742232
Keywords:
centrioles, biogenesis, microtubules, cell cycle, cell polarity, maturation

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Centrioles are essential cellular organelles that play a key role in cell division, cytoskeletal organization, and microtubule dynamics. Their unique structure and ability to self-replicate make centrioles indispensable for the regulation of cellular processes. This article focuses on the anatomy of centrioles, their biogenesis, and their role in cell biology.


The first part of the study describes the structural features of centrioles, including the ninefold symmetry that forms the foundation of their morphology. Special attention is given to centriole biogenesis, covering processes such as the initiation of assembly, the establishment of ninefold symmetry, microtubule assembly, and elongation. Mechanisms of temporal regulation, length control, and the formation of the distal end are also discussed. Additionally, the article examines centriole maturation processes and their functional significance in the context of the cell cycle, cell polarity, and intracellular transport.


The presented data are based on a review of contemporary studies, including structural models and biochemical mechanisms. This work highlights the importance of centrioles for understanding fundamental cellular biology processes and provides a foundation for further research into their roles in health and disease.

Article Details

Issue

Vol. 1 No. 2 (2025)

Section

Reviews and Perspectives
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in "Longevity Horizons" fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of old adult stem cells with Young, safe Adult Stem Cells induced from one's own cells.

How to Cite

Tkemaladze, J. (2025). Anatomy, Biogenesis, and Role in Cell Biology of Centrioles. Longevity Horizons, 1(2). DOI:https://doi.org/10.5281/zenodo.14742232
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