The Centriolar Theory of Differentiation Explains the Biological Meaning of the Centriolar Theory of Organismal Aging

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Published: 2025-02-20
DOI: https://doi.org/10.5281/zenodo.14897688
Keywords:
centrioles, aging, genomic instability, senescence, oxidative stress, stem cell dysfunction, biogerontology

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Centrioles, once thought to be simple structural components of the cell, have emerged as critical players in the aging process. This article reviews the existing theories linking centrioles to organismal aging, focusing on their roles in genomic stability, stem cell function, ciliary signaling, oxidative stress, and replicative Hyflick limit. Explored the evidence from model organisms, human studies, and clinical implications, highlighting the potential of centriole-targeted therapies to delay aging and prevent age-related diseases. By integrating findings from cellular biology, genetics, and clinical research, this article provides a comprehensive overview of the current understanding of centrioles in aging and outlines future directions for research and therapeutic development. The Centriolar Theory of Aging of the Organism is presented, which sees the accumulation of old, unrepairable centrioles in the organism as the main cause of the aging phenomenon. The biological meaning of this theory is explained by the Centriolar Theory of Differentiation, which links differentiation with centrioles. Thus, aging of the organism is not a separately programmed process or a separately stochastic process - both of these processes contribute. Aging of the organism is the result of the accumulation of old, unrepairable centrioles (stochastically accumulating defects) by the organism due to the implementation of differentiation programs (in the processes of development and then self-restoration).

Article Details

Issue

Vol. 1 No. 3 (2025)

Section

Reviews and Perspectives
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of Old Centrioles with Young Ones.

How to Cite

Tkemaladze, J. (2025). The Centriolar Theory of Differentiation Explains the Biological Meaning of the Centriolar Theory of Organismal Aging. Longevity Horizon, 1(3). DOI:https://doi.org/10.5281/zenodo.14897688
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