Anti-Blastomic Substances in the Plasma of Schizophrenia Patients: A Dual Role of Complement C4 in Synaptic Pruning and Tumor Suppression

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Published: 2025-03-18
DOI: https://doi.org/10.5281/zenodo.15042448
Keywords:
schizophrenia spectrum disorders, C4A genetic variants, synaptic refinement processes, complement cascade activation, anti-tumor immunity mechanisms, precision medicine strategies, integrative biomedical research

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Schizophrenia, a multifaceted neuropsychiatric disorder characterized by disruptions in neurodevelopmental trajectories, has been robustly linked to dysregulated synaptic pruning mechanisms and persistent immune system activation. The present study investigates the intricate interplay between the activity of the complement C4 gene—a pivotal regulator of synaptic pruning—and the incidence of malignant neoplasms in individuals diagnosed with schizophrenia. Our methodological approach integrated three primary investigative arms: (1) large-scale epidemiological meta-analyses encompassing a cohort of 15,000 patients, (2) in vitro experiments utilizing serum from schizophrenia patients to assess its impact on cancer cell proliferation, and (3) genetic profiling to quantify C4 expression patterns. Key findings revealed: (1) a statistically significant 20% reduction in cancer incidence among schizophrenia patients relative to the general population (p<0.01), (2) potent suppression of neoplastic cell growth (up to 40%) following exposure to patient-derived serum, and (3) a strong positive correlation between C4A allelic variants and anti-proliferative efficacy (r=0.58, p<0.001). We postulate that C4 hyperactivation in schizophrenia exerts dual biological effects: exacerbating synaptic elimination through microglial-mediated pruning while concurrently enhancing tumor surveillance via complement-dependent immunomodulation. These findings illuminate the pleiotropic nature of complement proteins in both neurodevelopmental pathology and oncological protection, offering novel therapeutic avenues for cancer management and schizophrenia pathobiology.

Article Details

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Vol. 1 No. 3 (2025)

Section

Research Article
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Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of Old Centrioles with Young Ones.

How to Cite

Tkemaladze, J. (2025). Anti-Blastomic Substances in the Plasma of Schizophrenia Patients: A Dual Role of Complement C4 in Synaptic Pruning and Tumor Suppression. Longevity Horizon, 1(3). DOI:https://doi.org/10.5281/zenodo.15042448
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