Mechanisms of Learning Through the Actualization of Discrepancies

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Published: 2025-04-12
DOI: https://doi.org/10.5281/zenodo.15200612
Keywords:
adaptive systems, model of the world, updating of discrepancies, reality manipulation, memory, forecasting, learning balance

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Adaptive systems, whether biological or artificial, rely on internal models to interact with their environment. This study investigates a learning mechanism driven by discrepancies between predictions and reality. A two-level computational system is analyzed: (1) passive pattern memorization and (2) active model correction. Key adaptive elements include fixed input-processing blocks (analogous to sensory channels), dynamic weight adjustments (memory-like), and a balance between model updating (learning acceleration) and stabilization. Memory plays a central role, with statistical data (*_tendency.csv) forming predictive foundations and an optimization algorithm refining them. Healthy adaptation requires equilibrium between plasticity and resilience. The framework demonstrates broad applicability, spanning AI and cognitive science. Unlike traditional views of memory as mere recall, this model emphasizes its dual role in both memorization and world-model formation, achieved through integrated memory functions. The results highlight memory’s potential as a core adaptive mechanism, bridging machine and biological learning. This approach advances AI development while offering novel insights into natural cognition, underscoring the parallels between artificial and biological adaptive systems.

Article Details

Issue

Vol. 1 No. 3 (2025)

Section

Technology and Innovations
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of Old Centrioles with Young Ones.

How to Cite

Tkemaladze, J. (2025). Mechanisms of Learning Through the Actualization of Discrepancies. Longevity Horizon, 1(3). DOI:https://doi.org/10.5281/zenodo.15200612
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References

Abraham, W. C., & Robins, A. (2005). Memory retention—the synaptic stability versus plasticity dilemma. Trends in Neurosciences, 28(2), 73-78. https://doi.org/10.1016/j.tins.2004.12.003

Anderson, J. R. (1983). The architecture of cognition. Harvard University Press.

Anderson, J. R., & Schooler, L. J. (1991). Reflections of the environment in memory. Psychological Science, 2(6), 396-408.

Aphkhazava, D., Sulashvili, N., & Tkemaladze, J. (2025). Stem Cell Systems and Regeneration. Georgian Scientists, 7(1), 271–319. doi: https://doi.org/10.52340/gs.2025.07.01.26

Ashby, F. G., & Maddox, W. T. (2005). Human category learning. Annual review of psychology, 56, 149-178.

Ashby, W. R. (1952). Design for a Brain. Chapman & Hall.

Aslin, R. N., & Newport, E. L. (2012). Statistical learning: From acquiring specific items to forming general rules. Current Directions in Psychological Science, 21(3), 170-176.

Badre, D., & Wagner, A. D. (2004). Neuron, 42(6), 939-947.

Barlow, H. (2001). Current Opinion in Neurobiology, 11(4), 475-486.

Barlow, H. B. (1972). Single units and sensation: a neuron doctrine for perceptual psychology? Perception, 1(4), 371-394.

Barlow, H. B. (1989). Unsupervised learning. Neural computation, 1(3), 295-311.

Bauer, P. J. (2006). Developmental Science, 9(2), 145-147.

Bear, M. F., & Abraham, W. C. (1996). Long-term depression in hippocampus. Annual review of neuroscience, 19(1), 437-462.

Behrens, T. E., et al. (2007). Nature Neuroscience, 10(9), 1214-1221.

Bengio, Y., Bengio, S., & Cloutier, J. (1991). Learning a synaptic learning rule. IJCNN-91-Seattle International Joint Conference on Neural Networks, 2, 969-974.

Bi, G.-Q., & Poo, M.-M. (2001). Annual Review of Neuroscience, 24, 139-166.

Bliss, T. V., & Collingridge, G. L. (1993). Nature, 361(6407), 31-39.

Bliss, T. V., & Lømo, T. (1973). Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path. The Journal of physiology, 232(2), 331-356.

Chichinadze, K. N., & Tkemaladze, D. V. (2008). Centrosomal hypothesis of cellular aging and differentiation. Advances in Gerontology= Uspekhi Gerontologii, 21(3), 367-371.

Chichinadze, K., Lazarashvili, A., & Tkemaladze, J. (2013). RNA in centrosomes: structure and possible functions. Protoplasma, 250(1), 397-405.

Chichinadze, K., Tkemaladze, D., & Lazarashvili, A. (2012). New class of RNA and centrosomal hypothesis of cell aging. Advances in Gerontology= Uspekhi Gerontologii, 25(1), 23-28.

Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012). A new class of RNAs and the centrosomal hypothesis of cell aging. Advances in Gerontology, 2(4), 287-291.

Chichinadze, K., Tkemaladze, J., & Lazarashvili, A. (2012). Discovery of centrosomal RNA and centrosomal hypothesis of cellular ageing and differentiation. Nucleosides, Nucleotides and Nucleic Acids, 31(3), 172-183.

Clark, A. (2013). Whatever next? Predictive brains, situated agents, and the future of cognitive science. Behavioral and Brain Sciences, 36(3), 181-204.

Clark, A. (2016). Surfing Uncertainty. Oxford University Press.

Cleeremans, A., Destrebecqz, A., & Boyer, M. (1998). Implicit learning: news from the front. Trends in cognitive sciences, 2(10), 406-416.

Cowan, N. (2005). Working memory capacity. Psychology Press.

Dayan, P., & Abbott, L. F. (2001). Theoretical neuroscience (Vol. 806). Cambridge, MA: MIT Press.

Dayan, P., & Daw, N. D. (2008). Decision theory, reinforcement learning, and the brain. Cognitive, Affective, & Behavioral Neuroscience, 8(4), 429-453. https://doi.org/10.3758/CABN.8.4.429

Dobkin, B. H. (2007). Brain-computer interface technology as a tool to augment plasticity and outcomes for neurological rehabilitation. The Journal of physiology, 579(3), 637-642.

Doya, K. (2002). Current Opinion in Neurobiology, 12(2), 217-222.

Dudai, Y. (2004). Science, 304(5667), 875-877.

Eichenbaum, H. (2017). Memory: Organization and control. Annual Review of Psychology, 68, 19-45. https://doi.org/10.1146/annurev-psych-010416-044131

Festinger, L. (1957). A Theory of Cognitive Dissonance. Stanford University Press.

Friston, K. (2005). Philosophical Transactions B, 360(1456), 815-836.

Friston, K. (2010). The free-energy principle: a unified brain theory? Nature reviews neuroscience, 11(2), 127-138.

Gershman, S. J. (2018). The successor representation: Its computational logic and neural substrates. Journal of Neuroscience, 38(33), 7193-7200. https://doi.org/10.1523/JNEUROSCI.0151-18.2018

Gershman, S. J., Blei, D. M., & Niv, Y. (2015). Context, learning, and extinction. Psychological review, 117(1), 197.

Gibson, E. J. (1969). Principles of perceptual learning and development. Appleton-Century-Crofts.

Goodfellow, I., Bengio, Y., & Courville, A. (2016). Deep learning. MIT press.

Goodfellow, I., et al. (2016). Deep Learning. MIT Press.

Grush, R. (2004). Behavioral and Brain Sciences, 27(3), 377-396.

Harmon-Jones, E., & Mills, J. (2019). American Psychologist, 74(7), 779-795.

Hassabis, D., Kumaran, D., Summerfield, C., & Botvinick, M. (2017). Neuroscience-inspired artificial intelligence. Neuron, 95(2), 245-258. https://doi.org/10.1016/j.neuron.2017.06.011

Hebb, D. O. (1949). The organization of behavior: A neuropsychological theory. Psychology Press.

Hohwy, J. (2013). The Predictive Mind. Oxford University Press.

Hubel, D. H., & Wiesel, T. N. (2005). Brain and visual perception: the story of a 25-year collaboration. Oxford University Press.

Jaba, T. (2022). Dasatinib and quercetin: short-term simultaneous administration yields senolytic effect in humans. Issues and Developments in Medicine and Medical Research Vol. 2, 22-31.

Kahneman, D. (1973). Attention and Effort. Prentice-Hall.

Kamin, L. J. (1969). Predictability, surprise, attention and conditioning. Punishment and aversive behavior, 4, 279-296.

Kandel, E. R. (2001). Science, 294(5544), 1030-1038.

Kandel, E. R., et al. (2013). Principles of Neural Science. McGraw-Hill.

Kipshidze, M., & Tkemaladze, J. (2023). Comparative Analysis of drugs that improve the Quality of Life and Life Expectancy. Junior Researchers, 1(1), 184–193. doi: https://doi.org/10.52340/2023.01.01.19

Kipshidze, M., & Tkemaladze, J. (2023). The planaria Schmidtea mediterranea as a model system for the study of stem cell biology. Junior Researchers, 1(1), 194–218. doi: https://doi.org/10.52340/2023.01.01.20

Kipshidze, M., & Tkemaladze, J. (2024). Abastumani Resort: Balneological Heritage and Modern Potential. Junior Researchers, 2(2), 126–134. doi: https://doi.org/10.52340/jr.2024.02.02.12

Kipshidze, M., & Tkemaladze, J. (2024). Balneology in Georgia: traditions and modern situation. Junior Researchers, 2(2), 78–97. doi: https://doi.org/10.52340/jr.2024.02.02.09

Kipshidze, M., & Tkemaladze, J. (2024). Microelementoses - history and current status. Junior Researchers, 2(2), 108–125. doi: https://doi.org/10.52340/jr.2024.02.02.11

Kirkpatrick, J., et al. (2017). Overcoming catastrophic forgetting in neural networks. PNAS, 114(13), 3521-3526. https://doi.org/10.1073/pnas.1611835114

Kober, J., Bagnell, J. A., & Peters, J. (2013). Reinforcement learning in robotics: A survey. The International Journal of Robotics Research, 32(11), 1238-1274. https://doi.org/10.1177/0278364913495721

Kriegeskorte, N., & Kievit, R. A. (2013). Nature Neuroscience, 16(9), 1140-1150.

Lake, B. M., Ullman, T. D., Tenenbaum, J. B., & Gershman, S. J. (2017). Building machines that learn and think like people. Behavioral and Brain Sciences, 40, e253. https://doi.org/10.1017/S0140525X16001837

LeCun, Y., Bengio, Y., & Hinton, G. (2015). Deep learning. Nature, 521(7553), 436-444. https://doi.org/10.1038/nature14539

Lezhava, T., Monaselidze, J., Jokhadze, T., Kakauridze, N., Khodeli, N., Rogava, M., Tkemaladze, J., ... & Gaiozishvili, M. (2011). Gerontology research in Georgia. Biogerontology, 12, 87-91. doi: 10.1007/s10522-010-9283-6. Epub 2010 May 18. PMID: 20480236; PMCID: PMC3063552

Löwel, S., & Singer, W. (1992). Science, 255(5045), 209-212.

Matsaberidze, M., Prangishvili, A., Gasitashvili, Z., Chichinadze, K., & Tkemaladze, J. (2017). TO TOPOLOGY OF ANTI-TERRORIST AND ANTI-CRIMINAL TECHNOLOGY FOR EDUCATIONAL PROGRAMS. International Journal of Terrorism & Political Hot Spots, 12.

McClelland, J. L., et al. (1995). Psychological Review, 102(3), 419-457.

McCloskey, M., & Cohen, N. J. (1989). Psychology of Learning and Motivation, 24, 109-165.

Norman, D. A. (2013). The design of everyday things. Basic books.

O'Keefe, J., & Dostrovsky, J. (1971). The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain research, 34(1), 171-175.

Pezzulo, G., Rigoli, F., & Friston, K. (2018). Hierarchical active inference: A theory of motivated control. Trends in cognitive sciences, 22(4), 294-306.

Prangishvili, A., Gasitashvili, Z., Matsaberidze, M., Chkhartishvili, L., Chichinadze, K., Tkemaladze, J., ... & Azmaiparashvili, Z. (2019). SYSTEM COMPONENTS OF HEALTH AND INNOVATION FOR THE ORGANIZATION OF NANO-BIOMEDIC ECOSYSTEM TECHNOLOGICAL PLATFORM. Current Politics and Economics of Russia, Eastern and Central Europe, 34(2/3), 299-305.

Rao, R. P., & Ballard, D. H. (1999). Nature Neuroscience, 2(1), 79-87.

Reber, A. S. (1993). Implicit learning and tacit knowledge: An essay on the cognitive unconscious. Oxford University Press.

Rescorla, R. A., & Wagner, A. R. (1972). A theory of Pavlovian conditioning: Variations in the effectiveness of reinforcement and nonreinforcement. Classical conditioning II: Current research and theory, 2, 64-99.

Schultz, W., Dayan, P., & Montague, P. R. (1997). A neural substrate of prediction and reward. Science, 275(5306), 1593-1599. https://doi.org/10.1126/science.275.5306.1593

Simon, H. A. (1956). Psychological Review, 63(2), 129-138.

Squire, L. R. (2004). Memory systems of the brain: a brief history and current perspective. Neurobiology of learning and memory, 82(3), 171-177.

Sutton, R. S., & Barto, A. G. (2018). Reinforcement learning: An introduction. MIT press.

Tkemaladze, J. (2023). Cross-senolytic effects of dasatinib and quercetin in humans. Georgian Scientists, 5(3), 138–152. doi: https://doi.org/10.52340/2023.05.03.15

Tkemaladze, J. (2023). Is the selective accumulation of oldest centrioles in stem cells the main cause of organism ageing?. Georgian Scientists, 5(3), 216–235. doi: https://doi.org/10.52340/2023.05.03.22

Tkemaladze, J. (2023). Long-Term Differences between Regenerations of Head and Tail Fragments in Schmidtea Mediterranea Ciw4. Available at SSRN 4257823.

Tkemaladze, J. (2023). Reduction, proliferation, and differentiation defects of stem cells over time: a consequence of selective accumulation of old centrioles in the stem cells?. Molecular Biology Reports, 50(3), 2751-2761.

Tkemaladze, J. (2023). Structure and possible functions of centriolar RNA with reference to the centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1), 156–170. doi: https://doi.org/10.52340/2023.01.01.17

Tkemaladze, J. (2023). The centriolar hypothesis of differentiation and replicative senescence. Junior Researchers, 1(1), 123–141. doi: https://doi.org/10.52340/2023.01.01.15

Tkemaladze, J. (2024). Absence of centrioles and regenerative potential of planaria. Georgian Scientists, 6(4), 59–75. doi: https://doi.org/10.52340/gs.2024.06.04.08

Tkemaladze, J. (2024). Cell center and the problem of accumulation of oldest centrioles in stem cells. Georgian Scientists, 6(2), 304–322. doi: https://doi.org/10.52340/gs.2024.06.02.32

Tkemaladze, J. (2024). Editorial: Molecular mechanism of ageing and therapeutic advances through targeting glycative and oxidative stress. Front Pharmacol. 2024 Mar 6;14:1324446. doi: 10.3389/fphar.2023.1324446. PMID: 38510429; PMCID: PMC10953819.

Tkemaladze, J. (2024). Elimination of centrioles. Georgian Scientists, 6(4), 291–307. doi: https://doi.org/10.52340/gs.2024.06.04.25

Tkemaladze, J. (2024). Main causes of intelligence decrease and prospects for treatment. Georgian Scientists, 6(2), 425–432. doi: https://doi.org/10.52340/gs.2024.06.02.44

Tkemaladze, J. (2024). The rate of stem cell division decreases with age. Georgian Scientists, 6(4), 228–242. doi: https://doi.org/10.52340/gs.2024.06.04.21

Tkemaladze, J. (2025). A Universal Approach to Curing All Diseases: From Theoretical Foundations to the Prospects of Applying Modern Biotechnologies in Future Medicine. doi: http://dx.doi.org/10.13140/RG.2.2.24481.11366

Tkemaladze, J. (2025). Aging Model - Drosophila Melanogaster. doi: http://dx.doi.org/10.13140/RG.2.2.16706.49607

Tkemaladze, J. (2025). Allotransplantation Between Adult Drosophila of Different Ages and Sexes. doi: http://dx.doi.org/10.13140/RG.2.2.27711.62884

Tkemaladze, J. (2025). Anti-Blastomic Substances in the Blood Plasma of Schizophrenia Patients. doi: http://dx.doi.org/10.13140/RG.2.2.12721.08807

Tkemaladze, J. (2025). Centriole Elimination as a Mechanism for Restoring Cellular Order. doi: http://dx.doi.org/10.13140/RG.2.2.12890.66248/1

Tkemaladze, J. (2025). Hypotheses on the Role of Centrioles in Aging Processes. doi: http://dx.doi.org/10.13140/RG.2.2.15014.02887/1

Tkemaladze, J. (2025). Limits of Cellular Division: The Hayflick Phenomenon. doi: http://dx.doi.org/10.13140/RG.2.2.25803.30249

Tkemaladze, J. (2025). Molecular Mechanisms of Aging and Modern Life Extension Strategies: From Antiquity to Mars Colonization. doi: http://dx.doi.org/10.13140/RG.2.2.13208.51204

Tkemaladze, J. (2025). Pathways of Somatic Cell Specialization in Multicellular Organisms. doi: http://dx.doi.org/10.13140/RG.2.2.23348.97929/1

Tkemaladze, J. (2025). Strategic Importance of the Caucasian Bridge and Global Power Rivalries. doi: http://dx.doi.org/10.13140/RG.2.2.19153.03680

Tkemaladze, J. (2025). Structure, Formation, and Functional Significance of Centrioles in Cellular Biology. doi: http://dx.doi.org/10.13140/RG.2.2.27441.70245/1

Tkemaladze, J. (2025). The Epistemological Reconfiguration and Transubstantial Reinterpretation of Eucharistic Practices Established by the Divine Figure of Jesus Christ in Relation to Theological Paradigms. doi: http://dx.doi.org/10.13140/RG.2.2.28347.73769/1

Tkemaladze, J. (2025). Transforming the psyche with phoneme frequencies "Habere aliam linguam est possidere secundam animam". doi: http://dx.doi.org/10.13140/RG.2.2.16105.61286

Tkemaladze, J. (2025). Uneven Centrosome Inheritance and Its Impact on Cell Fate. doi: http://dx.doi.org/10.13140/RG.2.2.34917.31206

Tkemaladze, J. (2025). Ze метод создания пластичного счетчика хронотропных частот чисел бесконечного потока информации. doi: http://dx.doi.org/10.13140/RG.2.2.29162.43207

Tkemaladze, J. (2025). Aging Model Based on Drosophila melanogaster: Mechanisms and Perspectives. Longevity Horizon, 1(3). doi: https://doi.org/10.5281/zenodo.14955643

Tkemaladze, J. (2025). Anatomy, Biogenesis, and Role in Cell Biology of Centrioles. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/zenodo.14742232

Tkemaladze, J. (2025). Anti-Blastomic Substances in the Plasma of Schizophrenia Patients: A Dual Role of Complement C4 in Synaptic Pruning and Tumor Suppression. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15042448

Tkemaladze, J. (2025). Asymmetry in the Inheritance of Centrosomes / Centrioles and Its Consequences. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/zenodo.14837352

Tkemaladze, J. (2025). Centriole Elimination: A Mechanism for Resetting Entropy in the Cell. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/zenodo.14876013

Tkemaladze, J. (2025). Concept to The Alive Language. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14688792

Tkemaladze, J. (2025). Concept to The Caucasian Bridge. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14689276

Tkemaladze, J. (2025). Concept to The Curing All Diseases. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14676208

Tkemaladze, J. (2025). Concept to The Eternal Youth. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14681902

Tkemaladze, J. (2025). Concept to The Food Security. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14642407

Tkemaladze, J. (2025). Concept to the Living Space. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14635991

Tkemaladze, J. (2025). Concept to The Restoring Dogmas. Longevity Horizon, 1(1). doi: https://doi.org/10.5281/zenodo.14708980

Tkemaladze, J. (2025). Differentiation of Somatic Cells in Multicellular Organisms. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/10.5281/zenodo.14778927

Tkemaladze, J. (2025). Long-Lived Non-Renewable Structures in the Human Body. doi: http://dx.doi.org/10.13140/RG.2.2.14826.43206

Tkemaladze, J. (2025). Memorizing an Infinite Stream of Information in a Limited Memory Space: The Ze Method of a Plastic Counter of Chronotropic Number Frequencies. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15170931

Tkemaladze, J. (2025). Molecular Insights and Radical Longevity from Ancient Elixirs to Mars Colonies. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/zenodo.14895222

Tkemaladze, J. (2025). Ontogenetic Permanence of Non-Renewable Biomechanical Configurations in Homo Sapiens Anatomy. Longevity Horizon, 1(3). doi : https://doi.org/10.5281/zenodo.15086387

Tkemaladze, J. (2025). Protocol for Transplantation of Healthy Cells Between Adult Drosophila of Different Ages and Sexes. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/zenodo.14889948

Tkemaladze, J. (2025). Replicative Hayflick Limit. Longevity Horizon, 1(2). doi: https://doi.org/10.5281/zenodo.14752664

Tkemaladze, J. (2025). Solutions to the Living Space Problem to Overcome the Fear of Resurrection from the Dead. doi: http://dx.doi.org/10.13140/RG.2.2.34655.57768

Tkemaladze, J. (2025). Systemic Resilience and Sustainable Nutritional Paradigms in Anthropogenic Ecosystems. doi: http://dx.doi.org/10.13140/RG.2.2.18943.32169/1

Tkemaladze, J. (2025). The Centriolar Theory of Differentiation Explains the Biological Meaning of the Centriolar Theory of Organismal Aging. Longevity Horizon, 1(3). doi:https://doi.org/10.5281/zenodo.14897688

Tkemaladze, J. (2025). The Concept of Data-Driven Automated Governance. Georgian Scientists, 6(4), 399–410. doi: https://doi.org/10.52340/gs.2024.06.04.38

Tkemaladze, J. (2025).Achieving Perpetual Vitality Through Innovation. doi: http://dx.doi.org/10.13140/RG.2.2.31113.35685

Tkemaladze, J. V., & Chichinadze, K. N. (2005). Centriolar mechanisms of differentiation and replicative aging of higher animal cells. Biochemistry (Moscow), 70, 1288-1303.

Tkemaladze, J., & Apkhazava, D. (2019). Dasatinib and quercetin: short-term simultaneous administration improves physical capacity in human. J Biomedical Sci, 8(3), 3.

Tkemaladze, J., & Chichinadze, K. (2005). Potential role of centrioles in determining the morphogenetic status of animal somatic cells. Cell biology international, 29(5), 370-374.

Tkemaladze, J., & Chichinadze, K. (2010). Centriole, differentiation, and senescence. Rejuvenation research, 13(2-3), 339-342.

Tkemaladze, J., & Samanishvili, T. (2024). Mineral ice cream improves recovery of muscle functions after exercise. Georgian Scientists, 6(2), 36–50. doi: https://doi.org/10.52340/gs.2024.06.02.04

Tkemaladze, J., Tavartkiladze, A., & Chichinadze, K. (2012). Programming and Implementation of Age-Related Changes. In Senescence. IntechOpen.

Tkemaladze, Jaba and Kipshidze, Mariam, Regeneration Potential of the Schmidtea Mediterranea CIW4 Planarian. Available at SSRN: https://ssrn.com/abstract=4633202 or http://dx.doi.org/10.2139/ssrn.4633202

Todorov, E. (2009). Efficient computation of optimal actions. PNAS, 106(28), 11478-11483. https://doi.org/10.1073/pnas.0710743106

Tulving, E. (2002). Annual Review of Psychology, 53, 1-25.

Turrigiano, G. G. (2008). The self-tuning neuron: Synaptic scaling of excitatory synapses. Cell, 135(3), 422-435. https://doi.org/10.1016/j.cell.2008.10.008

Wiener, N. (1948). Cybernetics. MIT Press.

Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чичинадзе, К. Н., Ткемаладзе, Д. В., & Азмайпарашвили, З. А. (2017). К топологии антитеррористических и антикриминальных технологии для образовательных программ. В научном издании представлены материалы Десятой международной научно-технической конфе-ренции «Управление развитием крупномасштабных систем (MLSD’2016)» по следующим направле-ниям:• Проблемы управления развитием крупномасштабных систем, включая ТНК, Госхолдин-ги и Гос-корпорации., 284.

Прангишвили, А. И., Гаситашвили, З. А., Мацаберидзе, М. И., Чхартишвили, Л. С., Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2017). & Азмайпарашвили, ЗА (2017). Системные составляющие здравоохранения и инноваций для организации европейской нано-биомедицинской екосистемной технологической платформы. Управление развитием крупномасштабных систем MLSD, 365-368.

Ткемаладзе, Д. В., & Чичинадзе, К. Н. (2005). Центриолярные механизмы дифференцировки и репликативного старения клеток высших животных. Биохимия, 70(11), 1566-1584.

Ткемаладзе, Д., Цомаиа, Г., & Жоржолиани, И. (2001). Создание искусственных самоадаптирующихся систем на основе Теории Прогноза. Искусственный интеллект. УДК 004.89. Искусственный интеллект. УДК 004.89.

Чичинадзе, К. Н., & Ткемаладзе, Д. В. (2008). Центросомная гипотеза клеточного старения и дифференциации. Успехи геронтологии, 21(3), 367-371.

Чичинадзе, К., Ткемаладзе, Д., & Лазарашвили, А. (2012). Новый класс рнк и центросомная гипотеза старения клеток. Успехи геронтологии, 25(1), 23-28.