Replicative Hayflick Limit

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Published: 2025-01-28
DOI: https://doi.org/10.5281/zenodo.14752664
Keywords:
replicative limit, replicative aging, replicometer, fibroblast cultures, telomeres

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Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

In the mid-20th century, Leonard Hayflick discovered that normal human cells have a limited number of divisions, which became a significant contribution to the study of replicative aging. Together with Paul Moorhead, he demonstrated that the replicative limit of cells is a fundamental biological feature. Their research led to the concept of the replicometer and the idea of telomeres as a mechanism that restricts cell divisions. Alexey Olovnikov proposed a hypothesis explaining the shortening of telomeres during each replication cycle. The discoveries of Hayflick, Olovnikov, and Blackburn laid the foundation for research into replicative immortality, which is of critical importance for understanding replicative aging and cancer. Research has identified the existence of two classes of cells—replicatively mortal and replicatively immortal. To this day, the replicometer remains to be discovered.

Article Details

Issue

Vol. 1 No. 2 (2025)

Section

Letters to the Editor
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Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of old adult stem cells with Young, safe Adult Stem Cells induced from one's own cells.

How to Cite

Tkemaladze, J. (2025). Replicative Hayflick Limit. Longevity Horizons, 1(2). DOI:https://doi.org/10.5281/zenodo.14752664
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