Ontogenetic Permanence of Non-Renewable Biomechanical Configurations in Homo Sapiens Anatomy

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Published: 2025-03-26
DOI: https://doi.org/10.5281/zenodo.15086387
Keywords:
aging, entropy, irreparable structures, centrioles, mitochondria, crystallins, neuronal DNA

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Aging in biological organisms is intricately linked to the accumulation of damage in long-lived irreparable structures, which remain unchanged throughout life. These structures include lens proteins (crystallins), DNA of postmitotic neurons, mitochondria of cardiomyocytes, tooth enamel, and centrioles of stem cells. Formed in the early stages of ontogenesis, they serve as "entropy accumulators"—a thermodynamic measure of molecular disorder. The impossibility of their replacement is dictated by evolutionary compromises: for instance, the stability of centrioles is crucial for the asymmetric division of stem cells, yet their selective inheritance results in the transfer of damage to progeny, thereby accelerating tissue aging. The accumulation of oxidized proteins, DNA mutations, and dysfunctional organelles disrupts homeostasis, triggering neurodegeneration, cataracts, and heart failure. This article examines the mechanisms underlying the damage to these structures, their role in age-related pathologies, and promising therapeutic strategies, including senolytics, CRISPR correction, and biomimetic materials. Special emphasis is placed on centrioles as key regulators of cellular entropy: while their stability supports tissue regeneration, defect accumulation leads to gene expression disruption and contributes to oncogenesis. Understanding the balance between longevity and vulnerability in irreparable structures opens new avenues for combating aging through targeted entropy management.

Article Details

Issue

Vol. 1 No. 3 (2025)

Section

Editorial
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of Old Centrioles with Young Ones.

How to Cite

Tkemaladze, J. (2025). Ontogenetic Permanence of Non-Renewable Biomechanical Configurations in Homo Sapiens Anatomy. Longevity Horizon, 1(3). DOI:https://doi.org/10.5281/zenodo.15086387
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