Molecular Insights and Radical Longevity from Ancient Elixirs to Mars Colonies

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Published: 2025-02-20
DOI: https://doi.org/10.5281/zenodo.14895222
Keywords:
aging, longevity, centrioles, stem cells, CRISPR, autophagy, biogerontology

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Aging is a complex biological process that has intrigued humanity for millennia, shaping cultural beliefs, scientific exploration, and medical advancements. From ancient Egyptian notions of "heart exhaustion" to contemporary models of cellular senescence, the perception of aging has evolved alongside technological progress. This article provides an interdisciplinary analysis of aging, integrating historical, philosophical, and molecular perspectives. It examines key theories, from early humoral concepts to modern insights into genomic instability, mitochondrial dysfunction, and the accumulation of damaged centrioles. Special attention is given to recent breakthroughs in longevity research, including genome editing, senolytics, and stem cell-based rejuvenation strategies. Advances in artificial intelligence and bioinformatics have further accelerated the search for geroprotective interventions, enabling the identification of novel molecular targets. Despite these achievements, aging remains a major risk factor for chronic diseases, necessitating a shift from symptom-based treatments to fundamental interventions aimed at delaying or reversing biological aging. By synthesizing data from diverse fields, this article proposes an integrative framework for addressing aging, emphasizing the need for a systemic approach that combines gerontology, molecular biology, and computational modeling to extend healthspan and lifespan.

Article Details

Issue

Vol. 1 No. 2 (2025)

Section

Technology and Innovations
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of Old Centrioles with Young Ones.

How to Cite

Tkemaladze, J. (2025). Molecular Insights and Radical Longevity from Ancient Elixirs to Mars Colonies. Longevity Horizon, 1(2). DOI:https://doi.org/10.5281/zenodo.14895222
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