Centriole Elimination: A Mechanism for Resetting Entropy in the Cell

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Published: 2025-02-15
DOI: https://doi.org/10.5281/zenodo.14876013
Keywords:
centrioles, elimination, entropy, totipotency, differentiation, aging

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

Centrioles are highly conserved organelles within the eukaryotic domain of life, playing an indispensable role in microtubule organization, cellular differentiation, and the formation of cilia and flagella. However, in the processes of oogenesis and spermatogenesis in certain organisms, centrioles undergo elimination, thereby preventing the transmission of either young or aged centrioles to the zygote, depending on the specific system of asymmetric division. The removal of centrioles in gametes can be interpreted as a mechanism of resetting cellular entropy and restoring totipotency, which is crucial for embryonic development. In somatic cells, centriole elimination is also observed during terminal differentiation, suggesting a potential connection to replicative aging. Research indicates that the programmed removal of centrioles is linked to degradation mechanisms involving microtubule breakdown and the ubiquitin-proteasome system. Centrioles are unique in the cellular architecture as they lack self-repair mechanisms, leading to the continuous accumulation of entropy, thereby contributing to cellular and organismal aging. Consequently, eliminating centrioles where they are no longer needed can be seen as a countermeasure against aging. Furthermore, centriole elimination plays a pivotal role in preventing centrosome-related pathologies, abnormal cell division, and possibly even oncogenesis. Investigating the mechanisms of centriole elimination opens promising avenues in biomedicine, including strategies for tissue rejuvenation and aging control.

Article Details

Issue

Vol. 1 No. 2 (2025)

Section

Reviews and Perspectives
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

Dr Jaba Tkemaladze is a Professor, a Scientist, and a President of Longevity Alliance Georgia.

Research Director at Longevity Clinic.

Replacing old adult stem cells with induced and safe young adult stem cells.

World-renowned scientist. Developed the Centriolar theory of differentiation and the Centriolar theory of organism ageing. With acquired experience in both academia and industry.

Training in medicine at Tbilisi State Medical University and then at the Psychiatry Research Institute further deepened my knowledge in the laboratory of the Institute of Morphology. Namely, combined experimental and computational methods to study the ageing process and the various ways of manipulating age-related diseases and improvement of human health.

Also served as a Scientific Advisory Board Member in Georgia's Ministry of Defense and Longevity Alliance. Published over 50 scientific articles, given over 100 invited talks and received several awards.

His Rejuvenation Formula: Rejuvenation = Replacement of Old Centrioles with Young Ones.

How to Cite

Tkemaladze, J. (2025). Centriole Elimination: A Mechanism for Resetting Entropy in the Cell. Longevity Horizon, 1(2). DOI:https://doi.org/10.5281/zenodo.14876013
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