Uznadze Set Revisited

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Published: 2025-11-13
DOI: https://doi.org/10.5281/zenodo.17609772
Keywords:
Set, Uznadze, Non-Conscious Regulation, Predictive Coding, Cognitive Rigidity, Cognitive Flexibility, Fronto-Striatal Circuits, Implicit Learning, Diagnostic Methodology

Main Article Content

Jaba Tkemaladze
Longevity Clinic
https://orcid.org/0000-0001-8651-7243

Abstract

The paradigm of set , developed by the Georgian psychologist D. Uznadze, represents a foundational yet often overlooked contribution to the science of non-conscious behavioral regulation. This article provides a comprehensive theoretical and experimental analysis of the set phenomenon, revisiting its core premise as a holistic, pre-conscious state that arises from the interaction of a subject's need and the objective situation, thereby determining the direction of subsequent mental activity. We systematically examine the classical haptic methodology—a two-phase experiment involving set-inducing and critical trials—and its modern modifications, including visual, computerized, and cross-modal paradigms that enhance its precision and scope. The analysis confirms the diagnostic power of set parameters, linking individual differences in set strength and lability to cognitive rigidity or flexibility, with significant implications for developmental, clinical, and neuropsychology. Furthermore, we integrate classical theory with contemporary neuroscience, framing set within the predictive coding framework and identifying its neurophysiological substrates in a distributed network including the basal ganglia for habit formation, the prefrontal cortex for cognitive control, and sensory association areas for perceptual integration. The article concludes by highlighting the paradigm's significant potential as a quantitative diagnostic tool and proposes future research directions, including the exploration of its neurochemical bases, its role in social cognition and implicit bias, and the development of cognitive training interventions to enhance behavioral flexibility.

Article Details

Issue

Vol. 1 No. 4 (2025)

Section

Reviews and Perspectives
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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Jaba Tkemaladze, Longevity Clinic

The Goal of Dr. Jaba Tkemaladze - Systemic Rejuvenation Through in Vitro–Derived Safe Adult Stem Cells and Their Transplantation. His theoretical works include the development of the Centriolar Theory of Differentiation and the Centriolar Theory of Organismal Aging, which suggest the role of centrioles in the aging and development of cells and tissues. President, Longevity Alliance Georgia. Head of Department, Longevity Clinic, Inc., Georgia.

 

A physician-scientist specializing in the biology of ageing and longevity. His research focuses on the potential of stem cell therapies for age-related diseases and healthspan extension.

Current Roles:

  • President, Longevity Alliance Georgia.
  • Head of Department, Longevity Clinic, Inc., Georgia.

Research Focus:
His main research is related to the study of methodologies for returning the regeneration rate to the indicators of 12-24 years, in particular with the potential application of the technology of producing young safe stem cells from one's own somatic cells. His theoretical works include the development of the Centriolar Theory of Differentiation and the Centriolar Theory of Organismal Aging, which suggest the role of centrioles in the aging and development of cells and tissues.

Background:
Dr. Tkemaladze received his medical education at the Tbilisi State Medical University and continued his research in the laboratories of the Institute of Morphology and the Research Institute of Psychiatry. In his work, he uses a combined approach, combining experimental and computational methods, to study the aging process and develop treatments for age-related diseases.

How to Cite

Tkemaladze, J. (2025). Uznadze Set Revisited. Longevity Horizon, 1(4). DOI:https://doi.org/10.5281/zenodo.17609772
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