Exploring the Chemical Composition, Therapeutic Properties, and Innovative Delivery Methods of Melissa officinalis

Abstract

Melissa officinalis L., colloquially termed lemon balm, stands as a preeminent medicinal herb lauded for its intricate phytochemical matrix and diverse therapeutic applications. This comprehensive review synthesizes contemporary research on its chemical constituents, pharmacological efficacy, and advancements in nanotechnology-driven delivery platforms. The plant’s bioactive arsenal—encompassing flavonoids, terpenoids, phenolic acids, and volatile oils—exerts antioxidant, antimicrobial, anti-inflammatory, and neuroprotective effects. Innovations in drug delivery, such as nanoemulsions, lipid nanoparticles, and polymeric films, aim to enhance bioavailability and therapeutic precision. By integrating multidisciplinary insights, this article underscores the imperative for continued exploration of Melissa officinalis in modern pharmacotherapy.