About the Journal

Editorial Policies & Journal Positioning

Longevity Horizon (Online ISSN: 3088-4063)

Journal Scope and Mission

Longevity Horizon is a peer-reviewed, open-access scientific journal dedicated to the rigorous study of biological aging, rejuvenation, and the fundamental mechanisms governing organismal decline and regeneration. The journal’s mission is to advance a quantitatively grounded, mechanistic understanding of aging and to promote reproducible, theory-driven interventions capable of extending healthy lifespan.

The journal operates at the intersection of theoretical biology, computational modeling, and empirical validation, with a strong emphasis on causal frameworks rather than descriptive correlations. We prioritize work that reframes aging as a tractable biological process governed by identifiable structural, cellular, and systemic constraints.

Focus and Scope

The journal welcomes original research articles, reviews, perspectives, and technical reports in areas including, but not limited to:

  • Mechanistic theories of aging and rejuvenation

  • Stem cell biology, asymmetric division, and cellular inheritance

  • Organelle-level determinants of aging (e.g., centrioles, mitochondria, cilia)

  • In vitro gametogenesis and regenerative reprogramming

  • Computational biology, predictive modeling, and virtual twin systems

  • Systems biology of aging and longevity interventions

  • Translational and preclinical rejuvenation strategies

Purely phenomenological studies without mechanistic insight are generally discouraged.

Editorial Structure and Scientific Pillars

The journal is structured around three core scientific pillars:

1. Theoretical Frameworks (TF)

This section publishes conceptual and mathematical models that establish new paradigms for understanding aging, rejuvenation, and biological time. Submissions must offer internally consistent, falsifiable frameworks with clear experimental or computational implications.

2. In Silico Experimentation (ISE)

This section emphasizes computational experimentation as a primary scientific instrument. Particular priority is given to work employing xTween virtual twin architectures, predictive simulations, and model-driven hypothesis generation capable of producing precise, testable biological predicates.

3. Empirical Investigations (EI)

This section publishes experimental and observational studies that rigorously test theoretical or computational predictions. Submissions are expected to include continuous, high-resolution data acquisition, preferably with 24/7 logging where biologically relevant, and to adhere to strict reproducibility and transparency standards.

Open Access Policy

Longevity Horizon is a fully open-access journal. All articles are published under the Creative Commons Attribution License (CC BY 4.0), permitting unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

The journal does not impose access barriers on readers and supports the global dissemination of longevity research.

Peer Review Policy

All submissions undergo single-blind peer review by at least two independent experts. Editorial decisions are based on scientific rigor, conceptual clarity, methodological soundness, and relevance to the journal’s mission.

The journal explicitly values negative results, replication studies, and theory-testing experiments, provided they are methodologically robust.

Ethics and Research Integrity

The journal adheres to internationally recognized ethical standards for research involving humans, animals, and biological materials. Authors must declare all potential conflicts of interest and funding sources.

Studies involving human-derived cells, embryos, or gametes must comply with applicable legal and ethical regulations and include explicit ethics approval statements.

Data Availability and Reproducibility

Authors are strongly encouraged to deposit raw data, processed datasets, and analysis code in recognized public repositories. Computational studies should provide sufficient methodological detail to enable independent reproduction of results.

Copyright Notice

Authors retain copyright of their work. By publishing in the journal, authors grant Longevity Horizon the right to publish and distribute the article under the CC BY 4.0 license.

Sponsorship and Independence

The journal operates independently of commercial influence. Any sponsorships or institutional affiliations are transparently disclosed and do not affect editorial decision-making.

Archiving and Preservation

The journal supports long-term digital preservation through participation in LOCKSS and CLOCKSS archival systems, ensuring permanent accessibility of published content.

History of the Journal

Longevity Horizon was founded to address the growing need for a dedicated, theory-driven platform in rejuvenation biology, emphasizing integration across scales—from subcellular structures to organismal systems.