Different Molecular Pathways of Cardiovascular Aging

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Published: 2025-03-20
DOI: https://doi.org/10.5281/zenodo.15059301
Keywords:
aging heart, cardiovascular aging, senescence, molecular pathways

Main Article Content

Mariam Beriashvili
Student at Tbilisi State Medical University
https://orcid.org/0009-0008-3419-3193

Abstract

Aging is an inevitable process that affects every living organism. It is a bodys response to a variety of stressors and is connected to many chronic diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), cardiovascular disease…  The aim of this review was to further comprehend the mechanisms of aging process and its effect on cardiovascular system. For collecting sufficient data, different scientific databases were used. In the end, there is no exact conclusion of exactly what causes aging, instead we have different theories of its molecular origins such as: oxidative stress, general wear-and-tear and genetic instability, mitochondrial genome damage, telomere shortening, genetic aging programs… Aging process, especially oxidative stress plays a major role in the pathophysiology of cardiomyocyte senescence. Biological compounds like MicroRNAs, SIR1 gene, NF-κB and IL-4, P66Shc, AMP-activated kinase (AMPK) has also been shown to participate or conduct molecular pathways that take part in aging process as well.

Article Details

Issue

Vol. 1 No. 3 (2025)

Section

Reviews and Perspectives
Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Articles published in Longevity Horizon fall under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND 4.0). This means authors retain their copyright while granting the journal the right to be the first publisher. Readers are permitted to share and distribute the work as long as proper credit is given. However, the content may not be altered, modified, or used for commercial purposes.

Author Biography

Mariam Beriashvili, Student at Tbilisi State Medical University

Mariam Beriashvili is affiliated with Tbilisi State Medical University (TSMU) in Tbilisi, Georgia. She has contributed to research in ,education, healthcare, biochemistry, and molecular biology.

How to Cite

Beriashvili, M. (2025). Different Molecular Pathways of Cardiovascular Aging. Longevity Horizon, 1(3). DOI:https://doi.org/10.5281/zenodo.15059301
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